Tonsillectomy combined with steroid pulse therapy: A curative therapy for IgA nephropathy
Tonsillectomy combined with steroid pulse therapy: A curative therapy for IgA nephropathy
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DOI：
10.1080/03655230410003387
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发表时间：
2004-12-01
影响因子：
1.4
通讯作者：
Hotta, O
中科院分区：
文献类型：
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作者：
Hotta, O
伊加肾病（IgAN）最初被认为是一种良性疾病。皮质类固醇的适应症由于其副作用而受到高度限制。并且考虑到风险/益处比，已经用于IgAN患者的特定亚组。然而，在过去的十年中，人们认识到IgAN的总体长期预后是一种非良性疾病。更积极的治疗。包括大剂量皮质类固醇和扁桃体切除术已被用于更广泛的IgAN患者亚组。于1988年我们已经用类固醇半脉冲疗法结合扁桃体切除术治疗IgAN患者。超过500名IgAN患者已经用该治疗方案治疗，并且高百分比的患者进入临床缓解，即，如果在早期阶段开始联合治疗，则没有泌尿异常。通过这些经验，我们认为IgAN患者的治疗目标应从“肾病进展”转向“临床缓解”。
As IgA nephropathy (IgAN) was originally regarded as a benign condition. the indication of corticosteroids ha been highly restricted because of their side effects. and has been used for a specific subgroup of IgAN patients with consideration of the risk/benefit ratio. During the last decade, however, with the recognition that the overall long-term prognosis of IgAN is a non-benign condition. more aggressive treatments. including high dose corticosteroids and tonsillectomy. have ben used for a wider subgroup of patients with IgAN. Since 1988. we have treated IgAN patients with steroid semi-pulse therapy combined with tonsillectomy. Over 500 patients with IgAN have been treated with this treatment protocol, and a high percentage of patients enter clinical remission, i.e. free from urinary abnormalities if the combination therapy was initiated in its earls, stage. Through these experiences we think the goal of treatment of IgAN patients should be changed front the progression of nephropathy" to "clinical remission".