Incideance and potential predictors of thromboembolic events in epithelial ovarian carcinoma patients during perioperative period
Incideance and potential predictors of thromboembolic events in epithelial ovarian carcinoma patients during perioperative period
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上皮性卵巢癌患者围手术期血栓栓塞事件的发生率和潜在预测因素
DOI：
10.1016/j.ejso.2020.01.026
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发表时间：
2020
期刊：
影响因子：
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通讯作者：
Ying Zhou
中科院分区：
文献类型：
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作者：
Qingqing Zhou;Chenchen Zhu;Zhen Shen;Tianjiao Zhang;Min Li;Jing Zhu;Jiwei Qin;Yanhu Xie;Wei Zhang;Rongzhu Chen;Guihong Wang;Lili Qian;Dabao Wu;Björn Nashan;Ying Zhou
目的：目的探讨卵巢上皮性癌（EOC）患者围手术期静脉血栓栓塞（VTE）的发生率及其危险因素。研究方法：对2017年1月至2019年7月在我院治疗的上皮性卵巢癌患者进行回顾性分析，并对医疗文件进行全面审查以收集相关数据。对EOC患者血栓形成的相关因素进行分析，采用单因素和多因素分析确定VTE的显著危险因素，并采用Bootstrap回归方法对多因素分析结果进行验证。采用ROC曲线法评价其对VTE的诊断价值。结果：233例EOC患者中，VTE的发生率为11.16%。根据多变量和5000个bootstrap样本分析，术前D-二聚体水平（>4.215 μg/ml，p = 0.041和p = 0.032）和合并脑梗死（p 50.5岁，p = 0.019和p = 0.002）和非最佳减瘤手术Bootstrap分析发现D-二聚体（>4.215 μg/ml）和肺结核对术后VTE的预测有统计学意义。结论：对EOC患者应采取更有效的血栓预防措施和试验前评估。术前D-二聚体水平（>4.215 μg/ml）是预测VTE事件的独立预测因子。年龄和减积手术是术后的独立预测因素。
Objective: To assess the incidence and the risk factors of venous thromboembolism (VTE) in patients with epithelial ovarian carcinoma (EOC) during the perioperative period..Methods: A retrospective analysis was conducted on the patients with epithelial ovarian cancer treated in our hospital, between January 2017 and July 2019, and a comprehensive review of the medical documentation was performed to collect relevant data. We then analyzed the related factors of the thrombosis in the EOC patients, using univariate and multivariate analysis to identify significant risk factors for VTE, and bootstrap resampling method was used to verify the multivariate analysis results. The ROC curve methods were conducted to evaluate the diagnostic value for the prediction of VTE..Results: We analyzed 233 cases of patients with EOC, of whom the incidence of VTE was 11.16%. According to multivariate and 5000 bootstrap samples analysis, preoperative D-dimer levels (>4.215 μg/ml, p = 0.041 and p = 0.032) and comorbid of cerebral infarction (p 50.5 years old, p = 0.019 and p = 0.002) and nonoptimal debulking surgery (p = 0.007 and p = 0.002) showed significance in predicting VTE after surgery; bootstrap analysis also found the D-dimer levels (>4.215 μg/ml) and tuberculosis had statistical significance..Conclusion: More effective thromboprophylaxis and pre-test assessment is necessary for EOC patients. For prediction VTE events, D-dimer levels (>4.215 μg/ml) were the independent predictors before operation. Age and debulking surgery were the independent predictors post operation.