HYPERTENSION, TRANSMURAL PRESSURE, AND VASCULAR SMOOTH-MUSCLE RESPONSE IN RATS
HYPERTENSION, TRANSMURAL PRESSURE, AND VASCULAR SMOOTH-MUSCLE RESPONSE IN RATS
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DOI：
10.1161/01.res.36.5.590
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发表时间：
1975-01-01
影响因子：
20.1
通讯作者：
BOHR, DF
中科院分区：
文献类型：
--
作者：
HANSEN, TR;BOHR, DF
使用一只髂外动脉慢性闭塞的大鼠研究跨壁压力对血管平滑肌反应性的影响。闭塞腿的动脉压降低至对侧未闭塞腿的大约一半。将自发性高血压大鼠和醋酸脱氧皮质酮诱导（DOCA）高血压大鼠的低压和高压股动脉螺旋带与正常血压对照的相应组织进行比较。当使用锶或镧作为激动剂时，自发性高血压大鼠的低压和高压动脉条的敏感性均高于对照组。当钾、肾上腺素或钙作为激动剂时，DOCA 高血压大鼠的低压和高压动脉试纸条的敏感性均高于对照组。在任何组的大鼠中，低压动脉和高压动脉的条带之间的敏感性没有差异。所有高血压大鼠双腿股动脉条的最大收缩力（收缩性）均降低。任何一种高血压大鼠的两个股动脉的 KCl 诱导的血管平滑肌收缩都不像正常血压大鼠那样容易被高钙浓度抑制。与高血压相关的敏感性和收缩力的变化不能通过降低自发性高血压大鼠的一条腿的血压来逆转，也不能通过在诱导 DOCA 高血压之前保护一条腿免受高压来预防。因此，这些高血压模型中动脉条的敏感性和收缩性的改变并不是继发于壁应力的增加。
The effect of transmural pressure on the responsiveness of vascular smooth muscle was studied using rats with chronic occlusion of one external iliac artery. The arterial pressure in the occluded leg was reduced to approximately half of that in the contralateral unoccluded leg. Helical strips from the low- and high-pressure femoral arteries of spontaneously hypertensive rats and rats with deoxycorticosterone acetate-induced (DOCA) hypertension were compared with corresponding tissues from normotensive controls. The sensitivity of both low- and high-pressure artery strips from the spontaneously hypertensive rat was greater than that of controls when strontium or lanthanum was used as the agonist. The sensitivity of strips from both low- and high-pressure arteries from the DOCA-hypertensive rat was greater than that of controls when potassium, epinephrine, or calcium was the agonist. There was no difference in sensitivity between strips from the low- and high-pressure arteries in any group of rats. Maximum contractile force (contractility) was reduced in femoral artery strips from both legs of all hypertensive rats. The KCl-induced contraction of vascular smooth muscle from both femoral arteries of either form of hypertensive rat was not as readily depressed by high calcium concentrations as was that from the normotensive rat. Changes in sensitivity and contractility associated with hypertension could not be reversed by lowering blood pressure in one leg of a spontaneously hypertensive rat or prevented by protecting one leg from high pressure prior to the induction of DOCA hypertension. The altered sensitivity and contractility of arterial strips in these models of hypertension are not, then, secondary to the increase in wall stress.