MK-801, AN N-METHYL-D-ASPARTATE RECEPTOR ANTAGONIST, BLOCKS QUINOLINIC ACID-INDUCED LIPID-PEROXIDATION IN RAT CORPUS STRIATUM
MK-801, AN N-METHYL-D-ASPARTATE RECEPTOR ANTAGONIST, BLOCKS QUINOLINIC ACID-INDUCED LIPID-PEROXIDATION IN RAT CORPUS STRIATUM
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DOI：
10.1016/0304-3940(93)90796-n
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发表时间：
1993-09-03
影响因子：
2.5
通讯作者：
RIOS, C
中科院分区：
文献类型：
--
作者：
SANTAMARIA, A;RIOS, C
In this study, we evaluate the possible participation of lipid peroxidation (LP) in the neurotoxic events that follow after quinolinic acid (QUIN) microinjection into the rat corpus striatum. Two hours after QUIN (240 nmol/mul) intrastriatal administration, lipid peroxidation was found increased by 32% vs. control as measured by thiobarbituric acid-reactive substances (TBARS). At the same time tested, the enhancement in LP was of 55% vs. control as measured by lipid flourescent products (LFP) formation (a second index of lipid peroxidation employed). The increase of QUIN-induced lipid peroxidation was completely abolished by pretreatment of rats with an N-methyl-D-aspartate (NMDA) receptor antagonist, MK-801 (10 mg/kg, i.p.), 60 min before QUIN microinjection. Results suggest an NMDA receptor involvement in the QUIN-induced oxidative processes.
