HERBOXIDIENE, A NEW HERBICIDAL SUBSTANCE FROM STREPTOMYCES-CHROMOFUSCUS A7847 - TAXONOMY, FERMENTATION, ISOLATION, PHYSICOCHEMICAL AND BIOLOGICAL PROPERTIES
HERBOXIDIENE, A NEW HERBICIDAL SUBSTANCE FROM STREPTOMYCES-CHROMOFUSCUS A7847 - TAXONOMY, FERMENTATION, ISOLATION, PHYSICOCHEMICAL AND BIOLOGICAL PROPERTIES
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DOI：
10.7164/antibiotics.45.914
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发表时间：
1992-06-01
影响因子：
3.3
通讯作者：
STONARD, R
中科院分区：
文献类型：
--
作者：
MILLERWIDEMAN, M;MAKKAR, N;STONARD, R
筛选微生物发酵液的除草活性，导致发现一种新的聚酮化合物，herboxidiene，从放线菌确定为一个成员的链霉菌chromofuscus集群。 作为培养基优化的结果，实现了除草剂二烯发酵生产的14至20倍增加。 采用连续反相C18步骤和SephadexLH-20层析纯化Herboxidene。 其分子式为C25 H42 O 6，通过HRFAB-MS测定。Herboxidene对多种杂草表现出非常有效的选择性除草活性，对小麦无活性，即使在高达5.6公斤/公顷的比率下也是如此。
Screening of microbial fermentation broths for herbicidal activity led to the discovery of a novel polyketide, herboxidiene, from an actinomycete identified as a member of the Streptomyces chromofuscus cluster. A 14- to 20-fold increase in fermentation production of herboxidiene was achieved as a result of media optimization. Herboxidiene was purified using successive reverse phase C18 steps and Sephadex LH-20 chromatography. Its molecular formula, C25H42O6, was determined by HRFAB-MS. Herboxidiene demonstrated exceptionally potent, selective, herbicidal activity against a variety of weed species and was inactive against wheat, even at rates as high as 5.6 kg/hectare.