Regulation of FGF-4 enhancer activity by transcription factor NF-Y.
Regulation of FGF-4 enhancer activity by transcription factor NF-Y.
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转录因子 NF-Y 对 FGF-4 增强子活性的调节。
DOI：
10.1006/bbrc.1995.1844
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发表时间：
1995
期刊：
影响因子：
--
通讯作者：
Lang,JC
中科院分区：
文献类型：
--
作者：
Bryans,M;Lucas,JM;Knobloch,TJ;Wilkie,NM;Lang,JC
FGF-4基因表达的调节受启动子中的元件和位于第三外显子非翻译区的增强子结构域控制。我们已经确定转录因子NF-Y与FGF-4启动子结合。我们通过突变分析进一步表明，NF-Y的结合对于FGF-4增强子活性是必需的，但对单独的FGF-4启动子活性的影响最小。
Regulation of FGF-4 gene expression is controlled both by elements in the promoter and by an enhancer domain located in the untranslated region of the third exon. We have determined that transcription factor NF-Y binds to the FGF-4 promoter. We further show by mutational analysis that binding of NF-Y is essential for FGF-4 enhancer activity but has minimal effect on activity of the FGF-4 promoter alone.