Localization of DER and the pattern of cell divisions in wild-type and Ellipse eye imaginal discs.
Localization of DER and the pattern of cell divisions in wild-type and Ellipse eye imaginal discs.
复制标题
野生型和椭圆眼成虫盘中 DER 的定位和细胞分裂模式。
DOI：
10.1016/0012-1606(92)90299-v
复制
发表时间：
1992
影响因子：
2.7
通讯作者：
Shilo,BZ
中科院分区：
文献类型：
--
作者：
Zak,NB;Shilo,BZ
果蝇的复眼由眼成虫盘中均匀的上皮细胞层发育而来。眼睛发育的一个有趣的方面是建立产生成熟小眼的光感受器簇的正确数量和间距。椭圆（Elp）被认为在这一过程中发挥了作用，因为Elp显性功能获得突变显着减少了复眼中光感受器簇的数量，而不影响形成的单个簇的形态（Baker和Rubin，1989）。由于El代表果蝇EGF受体(DER)基因座的等位基因，因此它编码在结构上能够介导诱导性细胞-细胞相互作用的蛋白质。为了更好地了解 DER 基因座在小眼模式中的作用，我们比较了 DER 蛋白在野生型和幼虫眼成虫盘中的定位。该受体的分布与其在光感受器簇前定位和分化的初始阶段介导细胞之间相互作用的概念一致。然而，Elp功能突变的基础不是DER蛋白的异位表达或增加。相反，EGF受体同系物的Elpform在正常定位中的表达导致形态发生沟后方细胞分裂的增殖模式的变化。
The compound eye ofDrosophiladevelops from a uniform layer of epithelial cells in the eye imaginal disc. One intriguing aspect of eye development is the establishment of the correct number and spacing of the photoreceptor clusters which give rise to the mature ommatidia.Ellipse(Elp) has been implicated as playing a role in this process because theElpdominant gain of function mutation dramatically reduces the number of photoreceptor clusters in the compound eye without affecting the morphology of individual clusters that are formed (Baker and Rubin, 1989). SinceElprepresents an allele of theDrosophilaEGF receptor (DER) locus, it encodes a protein which is structurally capable of mediating inductive cell-cell interactions. In an effort to better understand the role of the DER locus in ommatidial patterning, we compared the localization of DER protein in eye imaginal discs of wild-type andElplarvae. The distribution of this receptor is consistent with the notion of its mediating interactions between cells at the initial stages of photoreceptor precluster positioning and differentiation. However, the basis of theElpgain of function mutation is not ectopic or increased expression of the DER protein. Rather, expression of theElpform of the EGF receptor homolog in the normal localization leads to changes in the proliferative pattern of cells dividing posterior to the morphogenetic furrow.