Variation in oxytocin receptor density in the nucleus accumbens has differential effects on affiliative behaviors in monogamous and polygamous voles.
Variation in oxytocin receptor density in the nucleus accumbens has differential effects on affiliative behaviors in monogamous and polygamous voles.
复制标题
DOI：
10.1523/jneurosci.5039-08.2009
复制
发表时间：
2009-02-04
期刊：
影响因子：
--
通讯作者：
Young LJ
中科院分区：
文献类型：
--
作者：
Ross HE;Freeman SM;Spiegel LL;Ren X;Terwilliger EF;Young LJ
伏隔核中的催产素受体与社会一夫一妻制草原田鼠的异亲行为和配偶关系形成的调节有关。伏隔核中的催产素受体密度与幼年和成年雌性草原田鼠的异育呈正相关，注入伏隔核中的催产素受体拮抗剂可阻止这种行为。此外，与非一夫一妻制的啮齿类动物相比，草原田鼠的伏隔层催产素受体密度更高，阻断伏隔层催产素受体可以防止交配诱导的伴侣偏好形成。在这里，我们使用腺相关病毒载体基因转移来检查草原和草甸田鼠的累积催产素受体密度与社会行为之间的功能关系。伏隔核中催产素受体过度表达的成年雌性草原田鼠在与雄性同居后表现出加速的伴侣偏好形成，但没有表现出增强的异亲行为。然而，通过将催产素受体引入伏隔核，非一夫一妻制的草地田鼠并没有促进伴侣偏好。这些数据证实了伏隔核中催产素受体在调节雌性草原田鼠的伴侣偏好中的作用，并表明伏隔核中催产素受体的表达不足以促进非一夫一妻制物种的伴侣偏好。这些数据首次证明伏隔核中催产素受体密度与社会依恋行为变化之间存在直接关系。因此，纹状体中催产素受体表达的个体差异可能有助于社会行为的自然多样性。
Oxytocin receptors in the nucleus accumbens have been implicated in the regulation of alloparental behavior and pair bond formation in the socially monogamous prairie vole. Oxytocin receptor density in the nucleus accumbens is positively correlated with alloparenting in juvenile and adult female prairie voles, and oxytocin receptor antagonist infused into the nucleus accumbens blocks this behavior. Furthermore, prairie voles have higher densities of oxytocin receptors in the accumbens than non-monogamous rodent species, and blocking accumbal oxytocin receptors prevents mating-induced partner preference formation. Here we used adeno-associated viral vector gene transfer to examine the functional relationship between accumbal oxytocin receptor density and social behavior in prairie and meadow voles. Adult female prairie voles that over-express oxytocin receptor in the nucleus accumbens displayed accelerated partner preference formation after cohabitation with a male, but did not display enhanced alloparental behavior. However, partner preference was not facilitated in non-monogamous meadow voles by introducing oxytocin receptor into the nucleus accumbens. These data confirm a role for oxytocin receptor in the accumbens in the regulation of partner preferences in female prairie voles, and suggest that oxytocin receptor expression in the accumbens is not sufficient to promote partner preferences in non-monogamous species. These data are the first to demonstrate a direct relationship between oxytocin receptor density in the nucleus accumbens and variation in social attachment behaviors. Thus, individual variation in oxytocin receptor expression in the striatum may contribute to natural diversity in social behaviors.