ORAL-CONTRACEPTIVES AND RHEUMATOID-ARTHRITIS - NEW DATA FROM THE ROYAL-COLLEGE-OF-GENERAL-PRACTITIONERS ORAL CONTRACEPTION STUDY
ORAL-CONTRACEPTIVES AND RHEUMATOID-ARTHRITIS - NEW DATA FROM THE ROYAL-COLLEGE-OF-GENERAL-PRACTITIONERS ORAL CONTRACEPTION STUDY
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DOI：
10.1136/ard.49.10.744
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发表时间：
1990-10-01
影响因子：
27.4
通讯作者：
HIRSCH, S
中科院分区：
文献类型：
--
作者：
HANNAFORD, PC;KAY, CR;HIRSCH, S
根据1987年4月的数据，发现目前口服避孕药使用者和从未使用者之间的类风湿性关节炎标准化风险比为0.82（95%置信区间0.59至1.15），以前使用者和从未使用者之间的比率为0.94（95%置信区间0.72至1.22）。在我们的研究人群中出现了重要的长期趋势。在过去的二十年里，类风湿性关节炎的发病率在以前和从未使用者中有所下降。目前的使用者没有经历过这种暂时的趋势，因此，目前使用者和从未使用者之间的比率接近于1。这些长期变化可能解释了为什么一些研究发现口服避孕药具有保护作用，而其他研究则无法显示这种作用。
From data available at April 1987 it was found that the standardised risk ratio for rheumatoid arthritis between current users of oral contraceptives and never users was 0.82 (95% confidence interval 0.59 to 1.15) the ratio between former users and never users was 0.94 (95% confidence interval 0.72 to 1.22). Important secular trends have occurred within our study population. The incidence of rheumatoid arthritis among former and never users has declined over the past two decades. Current users have not experienced this temporal trend, and the ratio between current and never users has, therefore, approached unity. These secular changes may explain why some studies have found that oral contraceptives have a protective effect, while others have been unable to show such an effect.