Correlation of carotid atheromatous plaque inflammation using USPIO-enhanced MR imaging with degree of luminal stenosis
Correlation of carotid atheromatous plaque inflammation using USPIO-enhanced MR imaging with degree of luminal stenosis
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DOI：
10.1161/strokeaha.107.504753
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发表时间：
2008-07-01
期刊：
影响因子：
8.3
通讯作者：
Gillard, Jonathan H.
中科院分区：
文献类型：
--
作者：
Tang, Tjun Y.;Howarth, Simon P. S.;Gillard, Jonathan H.
Background and Purpose - Inflammation is a recognized risk factor for the vulnerable atherosclerotic plaque. The study explores the relationship between the degree of Magnetic Resonance (MR) - defined inflammation using Ultra Small Super-Paramagnetic Iron Oxide ( USPIO) particles and the severity of luminal stenosis in asymptomatic carotid plaques.Methods - Seventy-one patients with an asymptomatic carotid stenosis of >= 40% underwent multi-sequence USPIO-enhanced MR imaging. Stenosis severity was measured according to the NASCET and ECST methods.Results - No demonstrable relationship between inflammation as measured by USPIO-enhanced signal change and the degree of luminal stenosis was found.Conclusions - Inflammation and stenosis are likely to be independent risk factors, although this needs to be further validated.
