Wearable Microsensor Array for Multiplexed Heavy Metal Monitoring of Body Fluids
Wearable Microsensor Array for Multiplexed Heavy Metal Monitoring of Body Fluids
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DOI：
10.1021/acssensors.6b00287
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发表时间：
2016-07-01
期刊：
影响因子：
8.9
通讯作者：
Javey, Ali
中科院分区：
文献类型：
--
作者：
Gao, Wei;Nyein, Hnin Y. Y.;Javey, Ali
描述了一种灵活且可穿戴的微传感器阵列，用于同时多路监测人体体液中的重金属。选择锌、镉、铅、铜、汞离子作为目标分析物，在金、铋微电极上进行方波阳极溶出伏安法检测。这些金属的氧化峰通过结合皮肤温度传感器进行校准和补偿。提出了传感器阵列的高选择性、重复性和灵活性。采集人体汗液和尿液样本进行重金属分析，并通过电感耦合等离子体质谱(ICPMS)对微传感器的测量结果进行验证。通过骑自行车对受试者汗液中的重金属(如锌和铜)水平进行实时体内评估，以检查浓度随时间的变化。该平台有望提供有关个人健康状况的有洞察力的信息，如重金属暴露，并帮助相关的临床调查。
A flexible and wearable microsensor array is described for simultaneous multiplexed monitoring of heavy metals in human body fluids. Zn, Cd, Pb, Cu, and Hg ions are chosen as target analytes for detection via electrochemical square wave anodic stripping voltammetry (SWASV) on Au and Bi microelectrodes. The oxidation peaks of these metals are calibrated and compensated by incorporating a skin temperature sensor. High selectivity, repeatability, and flexibility of the sensor arrays are presented. Human sweat and urine samples are collected for heavy metal analysis, and measured results from the microsensors are validated through inductively coupled plasma mass spectrometry (ICP-MS). Real-time on-body evaluation of heavy metal (e.g., zinc and copper) levels in sweat of human subjects by cycling is performed to examine the change in concentrations with time. This platform is anticipated to provide insightful information about an individual's health state such as heavy metal exposure and aid the related clinical investigations.