The effects of fine and coarse particulate matter on lung function among the elderly
The effects of fine and coarse particulate matter on lung function among the elderly
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DOI：
10.1038/s41598-019-51307-5
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发表时间：
2019-10-15
影响因子：
4.6
通讯作者：
Guo, Yue-Liang Leon
中科院分区：
文献类型：
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作者：
Chen, Chi-Hsien;Wu, Chih-Da;Guo, Yue-Liang Leon
肺功能受损与老年人的发病率和死亡率相关。然而，关于颗粒物（PM）对老年人肺功能的长期影响的数据很少。本研究旨在探讨台湾地区老年人环境PM与不同肺功能指标之间的关系。2015年10月至2016年9月在台湾进行了一项年龄≥ 65岁的横断面调查。参加了每年的健康检查的老年人在不同背景PM浓度的五家医院入选。在每个受试者的住所，通过克里格法估计空气污染的长期（2015年的年平均浓度）暴露。通过线性回归模型评估了环境PM暴露与肺功能之间的关联，并对年龄、性别、身高、体重、教育程度、哮喘或慢性阻塞性肺病的存在、吸烟状况、季节和共污染物进行了调整。共有1241例受试者（平均年龄70.5岁）。2015年的平均住宅PM（2.5）和PM2.5-10分别为26.02和18.01 μ g/m3。调整混杂因素和共污染物后，FVC降低与细颗粒物（PM2.5）相关性最好，而FEV 1、FEF 25 - 75%、FEF（25）（%）和FEF50%降低与粗颗粒物（PM2.5-10）相关性最好。PM2.5的IQR（10 μ g/m3）增加使FVC减少106.38 ml（4.47%），而PM2.5-10的IQR（7.29 μ g/m3）增加使FEV 1和FEF 25 -75%分别减少91.23 ml（4.85%）和104.44 ml/s（5.58%）。在台湾老年人中，长期PM2.5暴露主要降低肺功能的肺活量。此外，PM2.5-10对气道传导功能的负面影响比PM2.5更强。
Impaired lung function is associated with morbidity and mortality in the elderly. However, there is a paucity of data regarding the long-term effects of particulate matter (PM) on lung function among the elderly. This study evaluated the exposure-response relationship between ambient PM and different lung function indices among the elderly in Taiwan. A cross-sectional survey of individuals aged >= 65 years was conducted in Taiwan from October 2015 to September 2016. Those who attended the annual health examination for the elderly in five hospitals of varying background PM concentrations were enrolled. The long-term (2015 annual mean concentration) exposure to air pollution was estimated by the Kriging method at the residence of each subject. The association between ambient PM exposure and lung function was evaluated by linear regression modeling, with adjustments for age, sex, height, weight, educational attainment, presence of asthma or chronic obstructive pulmonary disease, smoking status, season, and co-pollutants. There were 1241 subjects (mean age, 70.5 years). The mean residential PM(2.5 )and PM2.5-10 in 2015 was 26.02 and 18.01 mu g/m(3), respectively. After adjustments for confounders and co-pollutants, the FVC decrease was best associated with fine particles (PM2.5), whereas the FEV1, FEF25-75%, FEF(25)(% )and FEF50% decreases were best associated with coarse particles (PM2.5-10). An IQR (10 mu g/m(3)) increase in PM2.5 decreased FVC by 106.38 ml (4.47%), while an IQR (7.29 mu g/m(3)) increase in PM2.5-10 decreased FEV1 and FEF25-75% by 91.23 ml (4.85%) and 104.44 ml/s (5.58%), respectively. Among the Taiwanese elderly, long-term PM2.5 exposure mainly decreases the vital capacity of lung function. Moreover, PM2.5-10 has a stronger negative effect on the function of conductive airways than PM2.5.