Differential selection for B-raf and Ha-ras mutated liver tumors in mice with high and low susceptibility to hepatocarcinogenesis
Differential selection for B-raf and Ha-ras mutated liver tumors in mice with high and low susceptibility to hepatocarcinogenesis
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DOI：
10.1016/j.mrfmmm.2007.08.015
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发表时间：
2008-02-01
影响因子：
2.3
通讯作者：
Schwarz, Michael
中科院分区：
文献类型：
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作者：
Buchmann, Albrecht;Karcier, Zuleyha;Schwarz, Michael
RAS/Raf/MEK/ERK通路的激活在动物和人类肿瘤中经常被观察到。在我们的研究中，我们分析了C3H、B6C3F1和C56BL小鼠的肝肿瘤中B-RAF密码子637(以前的624)和Ha-ras密码子61的突变，这三种小鼠在肝癌发生的易感性上有很大的差异。总体而言，单独应用N-亚硝基二乙胺或7，12-二甲基苯并[a]蒽诱发的肿瘤中有73%(102/140)含有B-raf或Ha-ras突变，并且只有
Activation of the Ras/Raf/MEK/ERK pathway is frequently observed in animal and human tumors. In our study, we analyzed B-raf codon 637 (formerly 624) and Ha-ras codon 61 mutations in liver tumors from C3H, B6C3F1 and C56BL mice which differ considerably with regard to their susceptibility to hepatocarcinogenesis. In total, 73% (102/140) of tumors induced by a single application of N-nitrosodiethylamine or 7,12-dimethylbenz[a]anthracene contained either B-raf or Ha-ras mutations and only