NATURAL COURSE OF RETINITIS PIGMENTOSA OVER A 3-YEAR INTERVAL
NATURAL COURSE OF RETINITIS PIGMENTOSA OVER A 3-YEAR INTERVAL
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DOI：
10.1016/0002-9394(85)90351-4
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发表时间：
1985-01-01
影响因子：
4.2
通讯作者：
HANSON, AH
中科院分区：
文献类型：
--
作者：
BERSON, EL;SANDBERG, MA;HANSON, AH
94例6 - 49岁进行性视网膜色素变性患者在基线和连续3年每年检查一次视力、动态视野、黑暗适应阈值、计算机平均视网膜电图和眼底照片。一个子集在给定的访问后2个月内被召回，以测量访问间的可变性，并制定构成显著（P < 0.01）功能变化的标准。在3年的间隔中，86例患者中有66例（77%）在基线时可检测到反应，全场视网膜电图显著下降。患者每年平均损失16%至18.5%的剩余视网膜电图幅度和4.6%的剩余视野面积。76名患者中，有41名（54%）的骨刺色素沉着增加，这些患者在3年的间隔内进行了比较。视敏度和黑暗适应阈值保持相对稳定。
Patients (94) 6 to 49 yr old, with progressive forms of retinitis pigmentosa were examined at baseline and annually for 3 consecutive yr with respect to visual acuity, kinetic visual fields, dark-adaptation thresholds, computer-averaged electroretinograms and fundus photographs. A subset was recalled within 2 mo. of a given visit to measure intervisit variability and to develop criteria for what constitutes significant (P < 0.01) functional change. Over a 3-yr interval full-field electroretinograms declined significantly in 66 of 86 patients (77%) with detectable responses at baseline. Patients lost an average of 16% to 18.5% of remaining electroretinographic amplitude per yr and 4.6% of remaining visual field area per yr. Bone spicule pigmentation increased in 41 of 76 patients for whom comparisons were made over a 3-yr interval (54%). Visual acuity and dark-adaptation thresholds remained relatively stable.