Effects of sex and retention interval on the retrieval and extinction of auditory fear conditioning.
Effects of sex and retention interval on the retrieval and extinction of auditory fear conditioning.
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DOI：
10.3389/fnbeh.2022.1011955
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发表时间：
2022
影响因子：
3
通讯作者：
中科院分区：
文献类型：
--
作者：
恐惧记忆检索与创伤后应激障碍（PTSD）等精神疾病有关。创伤后应激障碍（PTSD）的标志性症状之一是，即使在创伤事件发生很久之后，仍会反复检索和重新体验最初的恐惧记忆。女性在遭受创伤后患 PTSD 的可能性几乎是男性的两倍，因此恐惧记忆检索的性别差异与理解 PTSD 的发展和维持高度相关。在当前的研究中，我们的目的是检查最近或遥远的恐惧记忆的检索和消除方面的性别差异。为此，我们在测试恢复和灭绝之前对雄性和雌性大鼠进行 1 天（最近）或 28 天（远程）条件调节。虽然性别或保留间隔对初始检索没有影响，但我们发现，在后来的检索/消除过程中，远程条件反射的雌性比远程条件反射的雄性表现出更高的冻结率，这表明在遥远的恐惧记忆的检索和/或消除中存在性别差异，但不是最近的恐惧记忆。总体而言，这些结果首次证明了远程恐惧记忆消退方面存在性别差异，这可能导致男性和女性与恐惧相关的疾病（如创伤后应激障碍）的差异表达。
Fear memory retrieval is relevant to psychiatric disorders such as post-traumatic stress disorder (PTSD). One of the hallmark symptoms of PTSD is the repeated retrieval and re-experiencing of the initial fear memory even long after the traumatic event has occurred. Women are nearly twice as likely to develop PTSD following a trauma than men, thus sex differences in the retrieval of fear memories is highly relevant for understanding the development and maintenance of PTSD. In the current study, we aimed to examine sex differences in the retrieval and extinction of either recent or remote fear memories. To do so, we conditioned male and female rats either 1 day (recent) or 28 days (remote) prior to testing retrieval and extinction. While there was no effect of sex or retention interval on initial retrieval, we found that remotely conditioned females exhibited higher rates of freezing than remotely conditioned males in later retrieval/extinction sessions, suggesting a sex difference in the retrieval and/or extinction of remote, but not recent, fear memories. Overall, these results are the first to demonstrate a sex difference in the extinction of remote fear memory, and this may contribute to the differential expression of fear-related disorders like PTSD in men and women.
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影响因子：
10.6
作者：
Gruene TM;Roberts E;Thomas V;Ronzio A;Shansky RM
通讯作者：
Shansky RM
影响因子：
16.6
作者：
Florido A;Velasco ER;Soto-Faguás CM;Gomez-Gomez A;Perez-Caballero L;Molina P;Nadal R;Pozo OJ;Saura CA;Andero R
通讯作者：
Andero R
影响因子：
4.8
作者：
Farrell K;Musaus M;Navabpour S;Martin K;Ray WK;Helm RF;Jarome TJ
通讯作者：
Jarome TJ
影响因子：
3.5
作者：
Chang, Yao-Ju;Yang, Chih-Hao;Hsu, Kuei-Sen
通讯作者：
Hsu, Kuei-Sen
DOI：
10.1037/h0027676
发表时间：
1969-01-01
期刊：
JOURNAL OF COMPARATIVE AND PHYSIOLOGICAL PSYCHOLOGY
影响因子：
--
作者：
BLANCHAR.RJ;BLANCHAR.DC
通讯作者：
BLANCHAR.DC