Symptomatic Infection is Associated with Prolonged Duration of Viral Shedding in Mild Coronavirus Disease 2019: A Retrospective Study of 110 Children in Wuhan
Symptomatic Infection is Associated with Prolonged Duration of Viral Shedding in Mild Coronavirus Disease 2019: A Retrospective Study of 110 Children in Wuhan
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DOI：
10.1097/inf.0000000000002729
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发表时间：
2020-07-01
影响因子：
3.6
通讯作者：
Du, Hao
中科院分区：
文献类型：
--
作者：
Lu, Yingying;Li, Yi;Du, Hao
背景：关于2019冠状病毒病（COVID-19）儿童病毒脱落的信息有限。本研究旨在探讨与轻度COVID-19儿童病毒脱落相关的临床和实验室特征。方法：回顾性分析武汉市儿童医院2020年1月30日至3月10日收治的110例新冠肺炎患儿的临床和实验室资料。结果：患者中位年龄为6岁。从发病到出院，COVID-19病毒脱落的中位时间为15天（四分位数间距[IQR]， 11-20天）。无症状患者（26.4%）比有症状患者（73.6%）更短（11天对17天）。多变量回归分析显示，年龄3.0 mg/L （OR 4.89; 95% CI: 1.10-21.75；P= 0.037）和胸片表现出现肺炎（OR 8.45; 95% CI: 2.69-26.61；P< 0.001）与症状性感染的几率增加相关。Kaplan-Meier分析显示有症状感染（P< 0.001）、发热（P= 0.006）、肺炎（P= 0.003）和淋巴细胞计数
Background: Information regarding viral shedding in children with coronavirus disease 2019 (COVID-19) was limited. This study aims to investigate the clinical and laboratory characteristics associated with viral shedding in children with mild COVID-19. Methods: The clinical and laboratory information of 110 children with COVID-19 at Wuhan Children's Hospital, Wuhan, China, from January 30 to March 10, 2020, were analyzed retrospectively. Results: The median age was 6 years old. The median period of viral shedding of COVID-19 was 15 days (interquartile range [IQR], 11-20 days) as measured from illness onset to discharge. This period was shorter in asymptomatic patients (26.4%) compared with symptomatic patients (73.6%) (11 days vs. 17 days). Multivariable regression analysis showed increased odds of symptomatic infection was associated with age 3.0 mg/L (OR 4.89; 95% CI: 1.10-21.75;P= 0.037) and presenting pneumonia in chest radiologic findings (OR 8.45; 95% CI: 2.69-26.61;P< 0.001). Kaplan-Meier analysis displayed symptomatic infection (P< 0.001), fever (P= 0.006), pneumonia (P= 0.003) and lymphocyte counts