NICOTINE ABSORPTION AND CARDIOVASCULAR EFFECTS WITH SMOKELESS TOBACCO USE - COMPARISON WITH CIGARETTES AND NICOTINE GUM
NICOTINE ABSORPTION AND CARDIOVASCULAR EFFECTS WITH SMOKELESS TOBACCO USE - COMPARISON WITH CIGARETTES AND NICOTINE GUM
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DOI：
10.1038/clpt.1988.107
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发表时间：
1988-07-01
影响因子：
6.7
通讯作者：
JACOB, P
中科院分区：
文献类型：
--
作者：
BENOWITZ, NL;PORCHET, H;JACOB, P
由于最近无烟烟草消费的复苏，无烟烟草的影响和健康后果引起了相当大的公共卫生兴趣。我们在10名健康志愿者中研究了无烟烟草（口吸鼻烟和咀嚼烟草）的尼古丁吸收程度和时间过程以及对心血管的影响，并将其与吸烟和咀嚼尼古丁口香糖进行了比较。尼古丁的最大水平相似，但由于长期吸收，与吸烟相比，单次暴露于无烟烟草后的尼古丁总暴露量是吸烟的两倍。所有烟草使用都会增加心率和血压，尽管有证据表明使用无烟烟草会对尼古丁的影响产生一定的耐受性，但总体心血管效应倾向于更大。使用尼古丁咀嚼胶时，观察到尼古丁水平相对较低，心血管反应较少。与尼古丁有关的吸烟对健康的不良影响预计与使用无烟烟草的危害相似。
Because of recent resurgence in its consumption, the effects and health consequences of smokeless tobacco are of considerable public health interest. We studied the extent and time course of absorption of nicotine and cardiovascular effects of smokeless tobacco (oral snuff and chewing tobacco) and compared it with smoking cigarettes and chewing nicotine gum in 10 healthy volunteers. Maximum levels of nicotine were similar but, because of prolonged absorption, overall nicotine exposure was twice as large after single exposures to smokeless tobacco compared with cigarette smoking. All tobacco use increased heart rate and blood pressure, with a tendency toward a greater overall cardiovascular effect despite evidence of development of some tolerance to effects of nicotine with use of smokeless tobacco. Relatively low levels of nicotine and lesser cardiovascular responses were observed with use of nicotine gum. Adverse health consequences of smoking that are nicotine related would be expected to present a similar hazard with the use of smokeless tobacco.