Pneumocystis jiroveci infection in patients with hyper-immunoglobulin E syndrome
Pneumocystis jiroveci infection in patients with hyper-immunoglobulin E syndrome
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DOI：
10.1542/peds.2006-0311
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发表时间：
2006-10-01
期刊：
影响因子：
8
通讯作者：
Holland, Steven M.
中科院分区：
文献类型：
--
作者：
Freeman, Alexandra F.;Davis, Joie;Holland, Steven M.
高免疫球蛋白E综合征是一种原发性免疫缺陷，其特征是复发性化脓性皮肤和肺脓肿、皮炎和血清免疫球蛋白E水平升高。氏肺囊虫（原卡氏肺囊虫）通常与高免疫球蛋白E综合征无关。我们发现7例高免疫球蛋白E综合征患者在呼吸或肺部病理标本中检测到耶氏弓形虫。在5例患者中，它是唯一的病原体，在另外2例患者中，它促成了多微生物病因学。没有给予一致的预防，长期随访中没有复发。我们的经验表明，在伴有或不伴有慢性肺部疾病的高免疫球蛋白E综合征患者中，耶氏杆菌均可引起肺炎。
The hyper-immunoglobulin E syndrome is a primary immunodeficiency characterized by recurrent pyogenic skin and lung abscesses, dermatitis, and elevated serum immunoglobulin E levels. Pneumocystis jiroveci (formerly Pneumocystis carinii) is not typically associated with hyper-immunoglobulin E syndrome. We identified 7 patients with hyper-immunoglobulin E syndrome with P jiroveci detected in respiratory or pulmonary pathology specimens. In 5 patients it was the sole pathogen, and in 2 other patients it contributed to a polymicrobial etiology. No consistent prophylaxis was given, and there have been no recurrences on long-term follow-up. Our experience suggests that P jiroveci can cause pneumonia in patients with hyper-immunoglobulin E syndrome both with and without chronic lung disease.