Action of nicotine on coronary vascular resistance in dogs.
Action of nicotine on coronary vascular resistance in dogs.
复制标题
尼古丁对狗冠状血管阻力的作用。
DOI：
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复制
发表时间：
1962
影响因子：
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通讯作者：
J. P. Long
中科院分区：
文献类型：
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作者：
F. Leaders;J. P. Long
尼古丁、去甲肾上腺素、乙酰胆碱、交感神经和副交感神经刺激对冠状动脉左降支灌注压的影响已被评估。尼古丁动脉内给药导致冠状动脉血管阻力增加，如冠状动脉灌注压增加所示。得出的结论是，这是交感神经系统活动或从嗜铬组织释放儿茶酚胺的结果。神经节或神经节样结构明显参与。其他药物和程序，试图本地化的尼古丁作用的网站进行了讨论。实验程序也用于测量心肌收缩力的制剂。冠状动脉内给予尼古丁或去甲肾上腺素和交感神经刺激可增加心肌的收缩力以及冠状动脉灌注压。这些药物和程序增加了冠状动脉血管阻力。迷走神经刺激或冠状动脉内注射乙酰胆碱通常会降低收缩力和冠状动脉灌注压。
The effect of nicotine, norepinephrine, acetylcholine, and sympathetic and parasympathetic nerve stimulation on perfusion pressure in the left descending coronary artery has been evaluated. Nicotine administered intra-arterially produced an increase in coronary vascular resistance as indicated by an increase in coronary perfusion pressure. It was concluded that this results from sympathetic nervous system activity or release of catecholamines from chromaffin tissue. Ganglia or ganglion-like structures are apparently involved. Other drugs and procedures that were used in attempting to localize the site of nicotine action are discussed. The experimental procedures were also used with preparations that measured myocardial force of contraction. The contractile force of the myocardium, as well as coronary perfusion pressure, was increased with intracoronary administration of nicotine or norepinephrine and sympathetic nerve stimulation. Coronary vascular resistance was increased by these agents and procedures. Vagal nerve stimulation or intracoronary administration of acetylcholine usually decreased the force of contraction and coronary perfusion pressure.