CENTRAL NERVOUS-SYSTEM REGULATION OF ADRENOCORTICOTROPIN SECRETION - ROLE OF SOMATOSTATINS
CENTRAL NERVOUS-SYSTEM REGULATION OF ADRENOCORTICOTROPIN SECRETION - ROLE OF SOMATOSTATINS
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DOI：
10.1210/endo-114-5-1546
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发表时间：
1984-01-01
期刊：
影响因子：
4.8
通讯作者：
VALE, W
中科院分区：
文献类型：
--
作者：
BROWN, MR;RIVIER, C;VALE, W
生长抑素-28（SS-28）和desAA 1，2，4，5，12，13[D-Trp 8]生长抑素（ODT 8-SS），但不生长抑素-14，脑室内给药，但静脉给药时不给药，抑制应激诱导的大鼠垂体ACTH和肾上腺髓质肾上腺素分泌。通过静脉注射抗促肾上腺皮质激素释放因子（CRF）的抗血清，可以完全防止尾部悬吊应激后ACTH的升高。SS-28和ODT 8-SS在体内或体外均不抑制CRF诱导的ACTH分泌。这些结果与SS-28和ODT 8-SS通过抑制CRF释放来防止应激诱导的ACTH分泌的假设一致。
Somatostatin-28 (SS-28) and desAA1,2,4,5,12,13[D-Trp8]somatostatin (ODT8-SS), but not somatostatin-14, given intracerebroventricularly, but not when given i.v., inhibit stress-induced pituitary ACTH and adrenomedullary epinephrine secretion in rats. The elevation of ACTH after tail suspension stress is totally prevented by i.v. administration of antisera raised against corticotropin-releasing factor (CRF). SS-28 and ODT8-SS do not inhibit CRF-induced ACTH secretion in vivo or in vitro. These results are consistent with the hypothesis that SS-28 and ODT8-SS prevent stres-induced ACTH secretion by inhibition of CRF release.