Connecting the Dots: Potential Interactions Between Sex Hormones and the Circadian System During Memory Consolidation.
Connecting the Dots: Potential Interactions Between Sex Hormones and the Circadian System During Memory Consolidation.
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DOI：
10.1177/07487304231184761
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发表时间：
2023-12
影响因子：
3.5
通讯作者：
Kwapis, Janine L.
中科院分区：
文献类型：
--
作者：
Boyd, Hannah M.;Frick, Karyn M.;Kwapis, Janine L.
生物钟和性激素信号都能强烈地影响大脑功能，但人们对这两个强大的调节系统如何在记忆巩固等复杂的神经过程中相互作用知之甚少。单独来说，这些系统的分子组成和作用已经被很好地描述了，但关于这些系统如何合作的信息却从根本上缺乏。在昼夜节律系统中，生物钟基因作为计时分子，在一个由视交叉上核控制的固定周期中传递一天中的时间信息。保持时间对于同步大脑和身体的各种生理过程尤其重要，包括那些调节记忆巩固的生理过程。同样，性激素是记忆的强大调节剂，雄激素、雌激素和黄体酮都会影响大脑中与记忆相关区域（如海马体）的记忆巩固。尽管有明确的证据表明，每个系统都可以单独影响记忆，但昼夜节律和荷尔蒙系统究竟是如何相互作用来影响记忆巩固的，目前还不清楚。在与记忆相关的大脑区域中，研究性激素作用或昼夜节律基因功能的研究揭示了这两个系统可能相互作用以控制记忆的几个值得注意的地方。在这里，我们把注意力放在生物钟和性激素信号之间已知的相互作用上。然后，我们回顾了性激素介导的记忆巩固控制，强调了在记忆形成过程中昼夜节律系统可能相互作用的潜在节点。我们认为，这两个系统之间的双向关系对于基于动物激素和昼夜节律状态的记忆形成的适当控制至关重要。
Both the circadian clock and sex hormone signaling can strongly influence brain function, yet little is known about how these 2 powerful modulatory systems might interact during complex neural processes like memory consolidation. Individually, the molecular components and action of each of these systems have been fairly well-characterized, but there is a fundamental lack of information about how these systems cooperate. In the circadian system, clock genes function as timekeeping molecules that convey time-of-day information on a well-stereotyped cycle that is governed by the suprachiasmatic nucleus. Keeping time is particularly important to synchronize various physiological processes across the brain and body, including those that regulate memory consolidation. Similarly, sex hormones are powerful modulators of memory, with androgens, estrogens, and progestins, all influencing memory consolidation within memory-relevant brain regions like the hippocampus. Despite clear evidence that each system can influence memory individually, exactly how the circadian and hormonal systems might interact to impact memory consolidation remains unclear. Research investigating either sex hormone action or circadian gene function within memory-relevant brain regions has unveiled several notable places in which the two systems could interact to control memory. Here, we bring attention to known interactions between the circadian clock and sex hormone signaling. We then review sex hormone–mediated control of memory consolidation, highlighting potential nodes through which the circadian system might interact during memory formation. We suggest that the bidirectional relationship between these two systems is essential for proper control of memory formation based on an animal’s hormonal and circadian state.
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