High-Resolution Nuclear Magnetic Resonance Study of 6-O-α-D-Glucopyranosyl-α-cyclodextrin-p-Nitrophenol Inclusion Complex in Aqueous Solution
High-Resolution Nuclear Magnetic Resonance Study of 6-O-α-D-Glucopyranosyl-α-cyclodextrin-p-Nitrophenol Inclusion Complex in Aqueous Solution
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水溶液中6-O-α-D-吡喃葡萄糖基-α-环糊精-对硝基苯酚包合物的高分辨率核磁共振研究
DOI：
10.1246/bcsj.62.2002
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发表时间：
1989
影响因子：
4
通讯作者：
S. Kobayashi
中科院分区：
文献类型：
--
作者：
Y. Kanda;Yasuhiko Yamamoto;Y. Inoue;R. Chǔjǒ;S. Kobayashi
用高分辨1H和13 C NMR对6-O-α-D-吡喃葡萄糖基-α-环糊精（G1-α-CD）-对硝基苯酚（pNP）包合物进行了表征。1H NMR结果表明，G1-α-CD与pNP在pD 7和pD 10时均能形成1：1的包合物，其包合解离常数与α-CD-pNP包合的解离常数相近，表明G1-α-CD和α-CD与pNP包合的能力相近。G1-α-CD-pNP复合物的几何构型与α-CD-pNP复合物相似。对G1-α-CD的NMR谱参数分析表明，G1-α-CD与pNP络合后，其不对称性增强。
6-O-α-D-Glucopyranosyl-α-cyclodextrin (G1-α-CD)-p-nitrophenol (pNP) inclusion complex has been characterized by high resolution 1H and 13C NMR. From 1H NMR measurements it is concluded that G1-α-CD forms a 1 : 1 inclusion complex with pNP at both pD 7 and 10, and the dissociation constants for their complexation are quite similar to those for α-CD–pNP complexation, suggesting that G1-α-CD and α-CD have a similar ability of complexation with pNP. The geometry of G1-α-CD–pNP complex was found to be similar to that of α-CD–pNP complex. Analysis on the NMR spectral parameters of G1-α-CD have revealed that the asymmetric nature of G1-α-CD molecule is enhanced by complexation with pNP.