Gold(I)‐Catalyzed One‐Pot Tandem Coupling/Cyclization: An Efficient Synthesis of Pyrrolo‐/Pyrido[2,1‐b]benzo[d][1,3]oxazin‐ 1‐ones
Gold(I)‐Catalyzed One‐Pot Tandem Coupling/Cyclization: An Efficient Synthesis of Pyrrolo‐/Pyrido[2,1‐b]benzo[d][1,3]oxazin‐ 1‐ones
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DOI：
10.1002/adsc.200900724
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发表时间：
2010-02
影响因子：
5.4
通讯作者：
Yu Zhou;Yun Zhai;Xun Ji;Guannan Liu;E. Feng;Deju Ye;Linxiang Zhao;Hualiang Jiang;Hong Liu
中科院分区：
文献类型：
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作者：
Yu Zhou;Yun Zhai;Xun Ji;Guannan Liu;E. Feng;Deju Ye;Linxiang Zhao;Hualiang Jiang;Hong Liu
A highly efficient method has been developed for the one-pot synthesis of multi-ring heterocyclic compounds such as pyrrolo-/pyrido[2,1-b]benzo[d][1,3]oxazin-1-ones from o-aminobenzyl alcohols via a gold(I)-catalyzed tandem coupling/ cyclization reaction. Significantly, the strategy presents a straightforward and efficient approach to construct novel tricyclic or polycyclic molecular architectures in which two new C-N bonds and one C-O bond are formed in a one-pot reaction operation from two simple starting materials. Moreover, a broad spectrum of substrates can participate in the process effectively to produce the desired products in good yields.
