Nocturnal oxygen saturation and painful sickle cell crises in children
Nocturnal oxygen saturation and painful sickle cell crises in children
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DOI：
10.1182/blood-2002-05-1392
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发表时间：
2003-02-01
期刊：
影响因子：
20.3
通讯作者：
Kirkham, FJ
中科院分区：
文献类型：
--
作者：
Hargrave, DR;Wade, A;Kirkham, FJ
镰状细胞病儿童急性疼痛危象的发病机制尚不清楚；提示的危险因素包括镰状细胞类型、贫血严重程度、胎儿血红蛋白浓度和上呼吸道阻塞引起的低氧血症。在一项包含95名患者的队列研究中，研究了临床、实验室和睡眠研究数据与疼痛危机发生频率之间的关系。单变量和多元回归模型均显示，夜间低血氧饱和度与儿童期疼痛危机发生率较高高度显著相关（P < 0.0001）。低氧血症的筛查和治疗可以减少这种疾病和其他并发症的发生频率。(C) 2003年由美国血液病学会出版。
The pathogenesis of acute painful crisis in children with sickle cell disease is poorly understood; suggested risk factors include sickle cell type, severity of anemia, fetal hemoglobin concentration, and hypoxemia from upper airway obstruction. In a cohort study of 95 patients the relationship between clinical, laboratory, and sleep study data and frequency of painful crisis was investigated. Both univariate and multiple regression modeling showed that low nocturnal oxygen saturation was highly significantly associated with a higher rate of painful crisis in childhood (P < .0001). Screening and treatment for hypoxemia may reduce the frequency of this and other complications of the disease. (C) 2003 by The American Society of Hematology.