Easykin: a flexible and user-friendly online tool for forensic kinship testing and missing person identification
Easykin: a flexible and user-friendly online tool for forensic kinship testing and missing person identification
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DOI：
10.1007/s00414-023-03083-1
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发表时间：
2023-09
影响因子：
2.1
通讯作者：
Ran Li;Nana Wang;Yu Zang;Jiajun Liu;Enlin Wu;R. Wu;Hongyu Sun
中科院分区：
文献类型：
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作者：
Ran Li;Nana Wang;Yu Zang;Jiajun Liu;Enlin Wu;R. Wu;Hongyu Sun
在法医学亲属关系鉴定和失踪人员鉴定中，选择信息量最大的参考亲属、选择合适的基因分型系统、综合评价证据的权重是一个基本问题。尽管已经开发了一些有用的工具，但它们并没有令人满意地解决这些问题。在本文中，我们开发了一个灵活的和用户友好的在线工具，Easykin，以解决上述问题。它有一些很有前途的特点：（i）谱系可以很容易地构建，并直观地显示，只需点击几下鼠标。(ii)系统功率可以在测试之前基于某些标志物和参考相关物的集合来估计。(iii)Easykin的修剪功能使用户能够选择可用参考的适当子集。(iv)单个病例在特定LR下的参数可能便于证据解释。(v)用户界面（UI）是基于HTML的仪表板，对专业和非专业用户都很友好，可以随时随地使用。在这里，我们提出了三个常见的情况下，作为例子，以证明如何亲属关系测试和失踪人员识别可以改善与EasyKin。总之，该工具为法医使用提供了一站式解决方案，即在测试前指导用户选择合适的试剂盒和参考亲属，在测试中计算LR，并在测试后提供用于数据解释的参数。EasyKinis可在https://forensicsysu.shinyapps.io/EasyKin/免费获得。
In forensic kinship testing and missing person identification, it is a fundamental question to choose the most informative reference relatives, select appropriate genotyping systems, and evaluate the weight of evidence comprehensively. Despite that several useful tools have been developed, they have not addressed these questions satisfactorily. In this paper, we develop a flexible and user-friendly online tool,Easykin, to address the aforementioned issues. It has some promising features: (i) Pedigrees can be constructed easily and presented intuitively with just a few mouse clicks. (ii) System power can be estimated before testing based on certain set of markers and reference relatives. (iii) The pruning function ofEasyKinenables users to choose appropriate subsets of available references. (iv) Parameters at a specific LR for a single case may ease evidence interpretation. (v) The user interface (UI) is an HTML-based dashboard, which is friendly to both professional and non-professional users and can be used anytime and anywhere. Here, we presented three common cases as examples to demonstrate how kinship testing and missing person identification can be improved withEasyKin. In conclusion, this tool provides a one-stop solution for forensic use, that is, instructing users to choose appropriate kits and reference relatives before testing, calculating LR in the testing, and providing parameters for data interpretation after testing.EasyKinis freely available at https://forensicsysu.shinyapps.io/EasyKin/.