Whole-genome sequencing of the snub-nosed monkey provides insights into folivory and evolutionary history.
Whole-genome sequencing of the snub-nosed monkey provides insights into folivory and evolutionary history.
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仰鼻猴的全基因组测序提供了对叶和进化历史的深入了解
DOI：
10.1038/ng.3137
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发表时间：
2014-12-01
期刊：
影响因子：
30.8
通讯作者：
Li, Ming
中科院分区：
文献类型：
--
作者：
Zhou, Xuming;Wang, Boshi;Li, Ming
Colobines是一种独特的旧世界猴子，主要吃树叶和种子，而不是水果和昆虫。我们报告了雄性金丝猴（Rhinopithecus roxellana）基因组的146* 覆盖率测序、从头组装和分析以及三个相关物种（Rhinopithecus bieti、Rhinopithecus brelichi和Rhinopithecus strykeri）的30* 覆盖率重测序。比较分析表明，亚洲colobines有一个增强的能力，从脂肪酸中获得能量和降解异生物质。我们在colobine RNASE1基因中发现了功能进化的证据，该基因编码一种关键的分泌型RNA酶，该酶能抑制来自共生菌群的高浓度细菌RNA。种群重建结果表明，古种群的有效大小分布与古种群的大小分布基本一致。roxellana更接近大熊猫，而不是它的同类。这些发现为哥伦比亚灵长类动物的饮食适应和进化历史提供了新的见解。
Colobines are a unique group of Old World monkeys that principally eat leaves and seeds rather than fruits and insects. We report the sequencing at 146* coverage, de novo assembly and analyses of the genome of a male golden snub-nosed monkey (Rhinopithecus roxellana) and resequencing at 30* coverage of three related species (Rhinopithecus bieti, Rhinopithecus brelichi and Rhinopithecus strykeri). Comparative analyses showed that Asian colobines have an enhanced ability to derive energy from fatty acids and to degrade xenobiotics. We found evidence for functional evolution in the colobine RNASE1 gene, encoding a key secretory RNase that digests the high concentrations of bacterial RNA derived from symbiotic microflora. Demographic reconstructions indicated that the profile of ancient effective population sizes for R. roxellana more closely resembles that of giant panda rather than its congeners. These findings offer new insights into the dietary adaptations and evolutionary history of colobine primates.