Therapeutic Potential of Autophagy in Glioblastoma Treatment With Phosphoinositide 3-Kinase/Protein Kinase B/Mammalian Target of Rapamycin Signaling Pathway Inhibitors.
Therapeutic Potential of Autophagy in Glioblastoma Treatment With Phosphoinositide 3-Kinase/Protein Kinase B/Mammalian Target of Rapamycin Signaling Pathway Inhibitors.
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自噬在磷酸肌醇 3-激酶/蛋白激酶 B/雷帕霉素信号通路抑制剂哺乳动物靶点治疗胶质母细胞瘤中的治疗潜力
DOI：
10.3389/fonc.2020.572904
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发表时间：
2020
影响因子：
4.7
通讯作者：
Dong L
中科院分区：
文献类型：
--
作者：
Xia Q;Xu M;Zhang P;Liu L;Meng X;Dong L
Glioblastoma (GB) is the most malignant and aggressive form of brain tumor, characterized by frequent hyperactivation of the phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) signaling pathway. PI3K/AKT/mTOR inhibitors have a promising clinical efficacy theoretically. However, strong drug resistance is developed in GB against the PI3K/AKT/mTOR inhibitors due to the cytoprotective effect and the adaptive response of autophagy during the treatment of GB. Activation of autophagy by the PI3K/AKT/mTOR inhibitors not only enhances treatment sensitivity but also leads to cell survival when drug resistance develops in cancer cells. In this review, we analyze how to increase the antitumor effect of the PI3K/AKT/mTOR inhibitors in GB treatment, which is achieved by various mechanisms, among which targeting autophagy is an important mechanism. We review the dual role of autophagy in both GB therapy and resistance against inhibitors of the PI3K/AKT/mTOR signaling pathway, and further discuss the possibility of using combinations of autophagy and PI3K/AKT/mTOR inhibitors to improve the treatment efficacy for GB. Finally, we provide new perspectives for targeting autophagy in GB therapy.
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影响因子：
45.3
作者：
Chakravarti, A;Zhai, G;Loeffler, JS
通讯作者：
Loeffler, JS
DOI：
10.1158/1078-0432.ccr-18-2204
发表时间：
2019-04-01
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
Haas NB;Appleman LJ;Stein M;Redlinger M;Wilks M;Xu X;Onorati A;Kalavacharla A;Kim T;Zhen CJ;Kadri S;Segal JP;Gimotty PA;Davis LE;Amaravadi RK
通讯作者：
Amaravadi RK
影响因子：
3.6
作者：
Aoki, Hiroshi;Takada, Yasunari;Kondo, Yasuko
通讯作者：
Kondo, Yasuko
影响因子：
5.4
作者：
Chang, Zhexing;Shi, Guang;Jia, Xiaojing
通讯作者：
Jia, Xiaojing
影响因子：
13.3
作者：
Aoki, Hiroshi;Kondo, Yasuko;Kondo, Seiji
通讯作者：
Kondo, Seiji