Epitope mapping of antibodies directed against the human neutrophil alloantigen 3a
Epitope mapping of antibodies directed against the human neutrophil alloantigen 3a
复制标题
针对人中性粒细胞同种抗原 3a 的抗体表位作图
作者：
Tom Berthold;J. Wesche;Kathleen Kuhnert;B. Fürll;Holger Hippe;J. Hoppen;A. Reil;Stefan Muschter;J. Bux;A. Greinacher
背景：严重输血相关急性肺损伤通常由针对人中性粒细胞同种异体抗原（HNA）-3a的抗体引起。HNA-3a是由胆碱转运蛋白样蛋白2（CTL 2）的第一个细胞外环中的氨基酸交换（Arg 154 Gln）产生的。HNA-3a抗体的结合结构域的特征未知。
BACKGROUND: Severe transfusion‐related acute lung injury is often caused by antibodies directed against the human neutrophil alloantigen (HNA)‐3a. HNA‐3a results from an amino acid exchange (Arg154Gln) in the first extracellular loop of the choline transporter‐like protein 2 (CTL2). The characteristics of the binding domain(s) of HNA‐3a antibodies are unknown.
血小板抗原 PlA1 和 PlA2 的功能重组表位的表达和纯化。
影响因子：
20.3
作者：
Barron-Casella,EA;Kickler,TS;Rogers,OC;Casella,JF
通讯作者：
Casella,JF