Functional variation of the dopamine D2 receptor gene is associated with emotional control as well as brain activity and connectivity during emotion processing in humans.
Functional variation of the dopamine D2 receptor gene is associated with emotional control as well as brain activity and connectivity during emotion processing in humans.
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DOI：
10.1523/jneurosci.3609-09.2009
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发表时间：
2009-11-25
期刊：
影响因子：
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通讯作者：
Bertolino A
中科院分区：
文献类型：
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作者：
Blasi G;Lo Bianco L;Taurisano P;Gelao B;Romano R;Fazio L;Papazacharias A;Di Giorgio A;Caforio G;Rampino A;Masellis R;Papp A;Ursini G;Sinibaldi L;Popolizio T;Sadee W;Bertolino A
与情绪处理相关的人格特征至少部分是可遗传和基因决定的。多巴胺 D2 受体信号传导参与情绪行为和相关大脑区域（如杏仁核和前额皮质）活动的调节。 D2 受体基因内的内含子单核苷酸多态性（DRD2，rs1076560，鸟嘌呤>胸腺嘧啶 - G>T）会改变两种蛋白质亚型（D2 短，D2S，主要是突触前）的剪接，并且与记忆表现和大脑活动的调节有关。在这里，我们的目的是研究 DRD2 rs1076560 基因型与情绪稳定性人格特征以及在处理情绪相关刺激期间与大脑生理学的关联。在 134 名健康受试者中评估了 DRD2 基因型和大五问卷评分，表明与 GT 受试者相比，GG 受试者的“情绪控制”能力有所下降。对 24 名个体样本进行的功能磁共振成像显示，与 GT 相比，GG 受试者在内隐处理过程中杏仁核活动更强，在面部情绪刺激外显处理过程中背外侧前额叶皮层 (DLPFC) 反应更强。其他结果还证明了 DRD2 基因型和面部情绪表达之间的相互作用，影响杏仁核和背外侧前额叶区域与重叠内侧前额叶区域的功能连接。此外，rs1076560 基因型与杏仁核/DLPFC 功能连接和情绪控制分数之间的差异关系相关。这些结果表明，基因决定的 D2 信号传导可以解释与情绪处理相关的部分人格特征以及特定大脑对情绪相关输入的反应的个体差异。
Personality traits related to emotion processing are, at least in part, heritable and genetically determined. Dopamine D2 receptor signaling is involved in modulation of emotional behavior and activity of associated brain regions such as the amygdala and the prefrontal cortex. An intronic single nucleotide polymorphism within the D2 receptor gene (DRD2, rs1076560, guanine>thymine - G>T) shifts splicing of the two protein isoforms (D2 short, D2S, mainly presynaptic, and D2 long, D2L) and has been associated with modulation of memory performance and brain activity. Here, our aim was to investigate the association of DRD2 rs1076560 genotype with personality traits of emotional stability and with brain physiology during processing of emotionally relevant stimuli. DRD2 genotype and Big Five Questionnaire scores were evaluated in 134 healthy subjects demonstrating that GG subjects have reduced ‘emotion control’ compared with GT subjects. fMRI in a sample of 24 individuals indicated greater amygdala activity during implicit processing and greater dorsolateral prefrontal cortex (DLPFC) response during explicit processing of facial emotional stimuli in GG subjects compared with GT. Other results also demonstrate an interaction between DRD2 genotype and facial emotional expression on functional connectivity of both amygdala and dorsolateral prefrontal regions with overlapping medial prefrontal areas. Moreover, rs1076560 genotype is associated with differential relationships between amygdala/DLPFC functional connectivity and emotion control scores. These results suggest that genetically determined D2 signaling may explain part of personality traits related to emotion processing and individual variability in specific brain responses to emotionally relevant inputs.