High expression of soluble CD155 in estrogen receptor-negative breast cancer
High expression of soluble CD155 in estrogen receptor-negative breast cancer
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DOI：
10.1007/s12282-019-00999-8
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发表时间：
2020-01-01
期刊：
影响因子：
4
通讯作者：
Shibuya, Kazuko
中科院分区：
文献类型：
--
作者：
Iguchi-Manaka, Akiko;Okumura, Genki;Shibuya, Kazuko
脊髓灰质炎病毒受体（CD 155）在造血细胞和非造血细胞上普遍表达，但其表达在多种肿瘤细胞中上调。在细胞毒性T淋巴细胞（CTL）和自然杀伤（NK）细胞上表达的活化受体DNAM-1与CD 155结合并介导CTL和NK细胞针对肿瘤的细胞毒性活性。与小鼠组织不同，人类组织表达可溶性形式的CD 155（sCD 155），其是缺乏跨膜区的CD 155的剪接同种型。我们以前报道过肺癌、胃肠道癌、乳腺癌和妇科癌患者的血清sCD 155水平高于健康献血员。在这里，我们专注于乳腺癌患者。方法采用双抗体夹心ELISA法检测153例乳腺癌患者血清sCD 155水平，分析sCD 155水平与乳腺癌临床病理参数的关系。结果乳腺癌患者血清sCD 155水平与患者年龄、疾病分期、浸润性肿瘤大小呈正相关。此外，它们在雌激素受体（ER）阴性癌症患者中高于ER阳性肿瘤患者，并且在Ki-67高癌症患者中高于Ki-67低癌症患者。结论血清sCD 155水平与乳腺癌高危因素相关。
Background The poliovirus receptor (CD155) is expressed ubiquitously at low levels on both hematopoietic and nonhematopoietic cells, but its expression is upregulated in various tumor cells. An activating receptor DNAM-1 expressed on cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells binds to CD155 and mediates the cytotoxic activity of CTLs and NK cells against tumors. Unlike mouse tissues, human tissues express a soluble form of CD155 (sCD155), which is a splicing isoform of CD155 lacking the transmembrane region. We previously reported that the serum levels of sCD155 were higher in lung, gastrointestinal, breast, and gynecologic cancer patients than in healthy donors. Here, we focus on breast cancer patients. Methods To analyze the association between serum level of sCD155 and clinicopathological parameters of breast cancer, we quantified sCD155 in the sera of 153 breast cancer patients by sandwich ELISA. Results sCD155 levels in the sera of breast cancer patients were positively correlated with patient age, disease stage, and invasive tumor size. Moreover, they were higher in patients with estrogen receptor (ER)-negative cancers than in those with ER-positive tumors, and higher in those with Ki-67-high cancers than in those with Ki-67-low cancers. Conclusions The serum level of sCD155 is correlated with high risk factors in breast cancer.