Brain regional synchronous activity predicts tauopathy in 3×TgAD mice.
Brain regional synchronous activity predicts tauopathy in 3×TgAD mice.
复制标题
DOI：
10.1016/j.neurobiolaging.2018.06.016
复制
发表时间：
2018-10
影响因子：
4.2
通讯作者：
Mattson MP
中科院分区：
文献类型：
--
作者：
Liu D;Lu H;Stein E;Zhou Z;Yang Y;Mattson MP
Alzheimer’s disease (AD) is characterized by progressive cognitive impairment and by extensive neuronal loss associated with extracellular amyloid β-peptide (Aβ) plaques and intraneuronal tau pathology in temporal and parietal lobes. AD patients are at increased risk for epileptic seizures, and data from experimental models of AD suggest that aberrant neuronal network activity occurs early in the disease process before cognitive deficits and neuronal degeneration. The contributions of Aβ and/or tau pathologies to dysregulation of neuronal network activity are unclear. Using a transgenic mouse model of AD (3 × TgAD mice) in which there occurs differential age-dependent development of tau and Aβ plaque pathologies, we applied analysis of resting state functional magnetic resonance imaging regional homogeneity, a measure of local synchronous activity, to discriminate the effects of Aβ and tau on neuronal network activity throughout the brain. Compared to age-matched wild-type mice, 6- to 8-month-old 3 × TgAD mice exhibited increased regional homogeneity in the hippocampus and parietal and temporal cortices, regions with tau pathology but not Aβ pathology at this age. By 18–24 months of age, 3 × TgAD mice exhibited extensive tau and Aβ pathologies involving the hippocampus and multiple functionally related brain regions, with a spatial expansion of increased local synchronous activity to include those regions. Our findings demonstrate that age-related brain regional hypersynchronous activity is associated with early tau pathology in a mouse model, consistent with a role for early tau pathology in the neuronal circuit hyperexcitability that is believed to precede and contribute to neuronal degeneration in AD.
登录
查看更多内容
影响因子：
4.8
作者：
Kazim SF;Chuang SC;Zhao W;Wong RK;Bianchi R;Iqbal K
通讯作者：
Iqbal K
DOI：
10.1523/jneurosci.3191-12.2013
发表时间：
2013-01-23
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Holth JK;Bomben VC;Reed JG;Inoue T;Younkin L;Younkin SG;Pautler RG;Botas J;Noebels JL
通讯作者：
Noebels JL
影响因子：
6.1
作者：
Garcia-Cabrero, Ana M.;Guerrero-Lopez, Rosa;Sanchez, Marina P.
通讯作者：
Sanchez, Marina P.
影响因子：
4.2
作者：
Haberman RP;Koh MT;Gallagher M
通讯作者：
Gallagher M
影响因子：
5.3
作者：
DeVos, Sarah L.;Goncharoff, Dustin K.;Miller, Timothy M.
通讯作者：
Miller, Timothy M.