Tissue water content in rats measured by desiccation
Tissue water content in rats measured by desiccation
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DOI：
10.1016/s1056-8719(97)00053-1
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发表时间：
1997-10-01
影响因子：
1.9
通讯作者：
Rowland, M
中科院分区：
文献类型：
--
作者：
Reinoso, RF;Telfer, BA;Rowland, M
将体重分别为200-250 g和270-430 g的两组大鼠的14个组织在40℃-50℃下干燥至恒重，测定组织含水量。水含量（平均值+/- SE；ml/g）在睾丸中最高（0.861 +/- 0.002），在脂肪中最低（0.183 +/- 0.017），其次是骨骼（0.446 +/- 0.017）和皮肤（0.651 +/- 0.007）。其余组织中的平均水含量为 0.763 (+/- 0.003)。对残留组织血液的水含量进行校正后，在脾、肺、肾、心、肝和脑中观察到未校正和校正的组织水之间存在显着差异。组织水与体重无关，左右肾、睾丸和骨骼的组织水相同。虽然肌肉（背部、腹部、后肢）和脂肪组织（肾周和皮下）的位置对水分含量没有影响，但对于皮肤来说，背部和腹部之间存在轻微差异。一般来说，目前的结果与综合文献值一致，但在一项研究中提供了用于开发基于生理学的大鼠药代动力学模型的所有组织的数据。 (C) 1997 爱思唯尔科学公司。
Tissue water content was determined by desiccation to constant weight at 40 degrees-50 degrees C in 14 tissues from two groups of rats weighing 200-250 and 270-430 g, respectively. The water content (mean +/- SE; ml/g) was highest in testes (0.861 +/- 0.002) and lowest in adipose (0.183 +/- 0.017) followed by bone (0.446 +/- 0.017) and skin (0.651 +/- 0.007). The average water content in the remaining tissues was 0.763 (+/- 0.003). Upon correction for the water content of residual tissue blood, significant difference between the uncorrected and corrected tissue water was observed for spleen, lungs, kidneys, heart, liver, and brain. Tissue water was independent of body weight, and was the same for right and left kidneys as well as testes and bone. Whereas the position of the muscle (back, abdomen, hindlimb) and adipose tissue (perirenal and subcutaneous) had no influence on water content, for skin, a slight difference was found between back and abdomen. In general, the current results are in agreement with composite literature values, but provide in one study data for all tissues used in the development of physiologically based pharmacokinetic models of rat. (C) 1997 Elsevier Science Inc.