Prevalence of Vitamin D deficiency in the North-West region of Russia: A cross-sectional study
Prevalence of Vitamin D deficiency in the North-West region of Russia: A cross-sectional study
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DOI：
10.1016/j.jsbmb.2016.03.026
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发表时间：
2016-11-01
影响因子：
4.1
通讯作者：
Grineva, E.
中科院分区：
文献类型：
--
作者：
Karonova, T.;Andreeva, A.;Grineva, E.
俄罗斯是一个具有发展维生素D缺乏症的地理和经济前提条件的国家。我们分析了俄罗斯西北部地区(北纬59-61度)居民的血清25(OH)D水平，以研究维生素D缺乏和缺乏的患病率及其与性别、年龄、肥胖和饮食的关系。研究人群包括1664名居民(1544名18-75岁的成年人)。和120名3-17岁的儿童/青少年)。采用电化学发光免疫分析法对1226例受试者血清25(OH)D进行测定。调查对象血清25(OH)D水平为9.8-147.5 nmol/L，成人平均为54.8+/-0.7nmol/L，儿童/青少年为-46.8+/-1.6nmol/L，16.8%的调查人群25(OH)D水平大于75nmol/L，37.5%为不足，45.7%为维生素D缺乏。血清25(OH)D水平女性低于男性(53.9+/-0.8和67.2+/-2.2nmol/L；p<；0.01)。我们没有发现维生素D状态和年龄之间的联系。体重指数正常者的25(OH)D水平高于超重和肥胖者(52.5±-2.8和44.8±2.0nmol/L，p<；0.05)。25(OH)D与BMI(r=-0.17，p=0.03)和WC(r=-0.15，p=0.02)呈负相关。问卷分析表明，定期摄入鱼类(每周最少一次)与较高的25(OH)D水平有关，而乳制品和维生素补充剂的摄入似乎对维生素D状态没有任何影响。这项研究表明，俄罗斯西北部地区成年人和青少年人群中维生素D缺乏和缺乏的发生率很高，血清25(OH)D水平低与女性、肥胖和低鱼制品饮食有关。(C)2016爱思唯尔有限公司。保留所有权利。
Russia is a country with geographic and economic preconditions for development of vitamin D deficiency. We analyzed serum 25(OH)D level in residents from North-West region (59-61 degrees North latitude) of Russia to study the prevalence of vitamin D insufficiency and deficiency and its associations with gender, age, obesity and diet. The study population included 1664 residents (1544 adults 18-75 y.o. and 120 children/adolescents of 3-17 y.o.). Serum 25(OH)D was determined in 1226 participants by electrochemiluminescence immunoassay. We used a questionnaire to check the frequency of dairy and fish products intake as well as the use of vitamin supplements.The serum 25(OH)D level was 9.8-147.5 nmol/L, mean level in adults population was 54.8 +/- 0.7 nMol/L, in children/adolescents-46.8 +/- 1.6 nmol/L. We revealed that 16.8% of the study population had a 25(OH) D level more than 75 nMol/L, 37.5% had insufficiency and 45.7% had vitamin D deficiency. Serum 25(OH)D level in women was lower than in men (53.9 +/- 0.8 and 67.2 +/- 2.2 nmol/L; p < 0.01). We did not find association between vitamin D status and age. Patients with normal BMI had higher 25(OH)D level than those with overweight and obesity (52.5 +/- 2.8 and 44.8 +/- 2.0 nmol/L, p < 0.05). Negative correlations between 25(OH)D and BMI (r = -0.17, p = 0.03) and WC (r = -0.15, p = 0.02) were found. Questionnaire analyses showed that regular fish intake (minimum once per week) was associated with higher 25(OH)D level, while dairy products and vitamin supplements intake did not seem to have any effect on vitamin D status.This study showed high prevalence of vitamin D insufficiency and deficiency in adults and adolescent population from North-West region of Russia, and an association of low serum 25(OH)D level with female gender, obesity and low fish products diet. (C) 2016 Elsevier Ltd. All rights reserved.