Photochemical transformations in salicylanilide photoallergy.
Photochemical transformations in salicylanilide photoallergy.
复制标题
水杨酰苯胺光过敏中的光化学转化。
DOI：
10.1111/j.1751-1097.1988.tb02709.x
复制
发表时间：
1988
影响因子：
3.3
通讯作者：
Yoon,UC
中科院分区：
文献类型：
--
作者：
Epling,GA;Wells,JL;Yoon,UC
通过对3，3 ′，4 ′，5-四氯水杨酰苯胺的初级和次级光产物的分离和光谱测定，研究了其光化学转化过程。光反应性干净地涉及光化学脱氯;三个氯最终以有效的逐步方式损失。一个自由基的机制牵连的二聚体的形成和氢原子提取半胱氨酸时，存在于光解过程中。在HSA或BSA的存在下，初始脱卤导致与蛋白质的光加合物，但主要光产物三氯化合物的脱卤不会导致与蛋白质的有效光结合。
The photochemical transformations of 3,3′,4′,5‐tetrachlorosalicylanilide, have been characterized by isolation and spectroscopic determination of the primary and secondary photoproducts. The photoreactivity cleanly involves photochemical dechlorination; three chlorines are ultimately lost in an efficient stepwise fashion. A radical mechanism was implicated by formation of a dimer and hydrogen atom abstraction from cysteine when present during photolysis. In the presence of HSA or BSA, the initial dehalogenation leads to a photoadduct with the protein, but dehalogenation of the primary photoproduct, a trichloro compound, does not lead to an efficient photobinding to protein.