Production of Highly Charged Pharmaceutical Aerosols Using a New Aerosol Induction Charger.
Production of Highly Charged Pharmaceutical Aerosols Using a New Aerosol Induction Charger.
复制标题
使用新的气溶胶感应充电器生产高电荷的药物气溶胶。
DOI：
10.1007/s11095-015-1682-6
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发表时间：
2015-09
影响因子：
3.7
通讯作者：
Hindle M
中科院分区：
文献类型：
--
作者：
Golshahi L;Longest PW;Holbrook L;Snead J;Hindle M
适当带电的粒子可用于药物气雾剂的有效肺靶向。这项研究的目的是描述一种新型感应充电器的性能，该充电器与网状雾化器一起工作，产生高电荷的亚微米气雾剂，绕过口腔-喉咙，将临床相关剂量的药物输送到肺部。感兴趣的变量包括模型药物(即硫酸沙丁胺醇)和充电辅料(氯化钠)的组合以及充电电场的强度(1-5千伏/厘米)。用改进的低压电撞机系统结合高效液相色谱仪测量气溶胶的电荷和大小。在接近气溶胶质量中值空气动力学直径(~0.4μm)时，粒子上的感应电荷比电场和扩散电荷的极限高出一个数量级。雾化速率为439.3±42.9min，雾化浓度为0.1wv/μ，雾化速率为419.5±34.2min/min，雾化速率为419.5±34.2min/min，雾化速率为419.5±34.2min/μ。建立了一个新的关联式来预测感应充电器产生的粒子电荷。气溶胶感应充电器和预测相关性的结合将允许实际产生和控制带电的亚微米气溶胶，以定向在肺部沉积。
Properly charged particles can be used for effective lung targeting of pharmaceutical aerosols. The objective of this study was to characterize the performance of a new induction charger that operates with a mesh nebulizer for the production of highly charged submicrometer aerosols to bypass the mouth-throat and deliver clinically relevant doses of medications to the lungs. Variables of interest included combinations of model drug (i.e. albuterol sulfate) and charging excipient (NaCl) as well as strength of the charging field (1–5 kV/cm). Aerosol charge and size were measured using a modified electrical low pressure impactor system combined with high performance liquid chromatography. At the approximate mass median aerodynamic diameter (MMAD) of the aerosol (~ 0.4 μm), the induction charge on the particles was an order of magnitude above the field and diffusion charge limit. The nebulization rate was 439.3 ± 42.9 μl/min, which with a 0.1 % w/v solution delivered 419.5 ± 34.2 μg of medication per minute. A new correlation was developed to predict particle charge produced by the induction charger. The combination of the aerosol induction charger and predictive correlations will allow for the practical generation and control of charged submicrometer aerosols for targeting deposition within the lungs.