Permeable Self-Assembled Molecular Containers for Catalyst Isolation Enabling Two-Step Cascade Reactions
Permeable Self-Assembled Molecular Containers for Catalyst Isolation Enabling Two-Step Cascade Reactions
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DOI：
10.1021/jacs.7b02745
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发表时间：
2017-05-03
影响因子：
15
通讯作者：
Fujita, Makoto
中科院分区：
文献类型：
--
作者：
Ueda, Yoshihiro;Ito, Hiroaki;Fujita, Makoto
建立一个通用的一锅级联反应方案将大大减少多步有机合成的工作量。我们证明了M（12）L24自组装复合物的独特结构使它们有可能作为催化剂载体，实现连续的化学转化。一个立体选择性级联反应（烯丙基氧化，然后Diels-Alder环化）与两个本质上不相容的催化剂进行了演示。我们的系统在可用性、可扩展性和可预测性方面具有优势。
Establishment of a general one-pot cascade reaction protocol would dramatically reduce the effort of multistep organic synthesis. We demonstrate that the unique structure of M(12)L24 self-assembled complexes gives them the potential to serve as catalyst carriers for enabling continuous chemical transformations. A stereoselective cascade reaction (allylic oxidation followed by Diels-Alder cyclization) with two intrinsically incompatible catalysts was demonstrated. Our system is advantageous in terms of availability, scalability, and predictability.