Expression and Function of miR-155 in Diseases of the Gastrointestinal Tract.
Expression and Function of miR-155 in Diseases of the Gastrointestinal Tract.
复制标题
miR-155 在胃肠道疾病中的表达和功能
DOI：
10.3390/ijms17050709
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发表时间：
2016-05-11
影响因子：
5.6
通讯作者：
Lu N
中科院分区：
文献类型：
--
作者：
Wan J;Xia L;Xu W;Lu N
MicroRNAs(MiRNAs)是一种在生理和病理生理条件下调节靶基因表达的非编码小RNA。MIR-155是一种多功能的miRNA，具有炎症相关和致癌作用。尤其是miR-155的异常调节，除了参与重要靶点和信号通路的分子变化外，还与幽门螺杆菌相关性胃病、炎症性肠病和结直肠癌密切相关。本文就miR-155在炎症和癌变过程中的表达和功能及其作为某些胃肠道疾病有效治疗靶点的研究进展作一综述。
MicroRNAs (miRNAs) are a type of small noncoding RNA that can regulate the expression of target genes under physiological and pathophysiological conditions. miR-155 is a multifunctional miRNA with inflammation-related and oncogenic roles. In particular, the dysregulation of miR-155 has been strongly implicated in Helicobacter pylori-related gastric disease, inflammatory bowel disease, and colorectal cancer in addition to being involved in molecular changes of important targets and signaling pathways. This review focuses on the expression and function of miR-155 during inflammation and carcinogenesis and its potential use as an effective therapeutic target for certain gastrointestinal diseases.