Cortisol correlates with metabolic disturbances in a population study of type 2 diabetic patients
Cortisol correlates with metabolic disturbances in a population study of type 2 diabetic patients
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DOI：
10.1530/eje.1.02074
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发表时间：
2006-02-01
影响因子：
5.8
通讯作者：
Peters, A
中科院分区：
文献类型：
--
作者：
Oltmanns, KM;Dodt, B;Peters, A
目的：2型糖尿病的患病率在工业化国家迅速增加，肾上腺糖皮质激素可能会加重这种疾病。我们寻求：设计：我们调查了190名2型糖尿病患者，他们自愿参加了一项在吕贝克及其郊区的12430人的人口研究。目标人群包括1939年至1958年出生的男性和女性，他们最初收到了关于其健康状况的邮寄问卷。我们确定了346例确诊为糖尿病的受试者，216例患者参加了研究。方法：在午餐前后、晚上和第二天早上站立前后收集五份唾液皮质醇样本。与糖尿病相关的临床变量进行了测量，并与皮质醇concentration.Results：没有一个队列的唾液皮质醇浓度超过了正常接受的范围。根据标准午餐前收集的皮质醇样本，将队列分为三分之一。皮质醇与血、尿糖、餐后血糖、糖化血红蛋白、收缩压、舒张压呈正相关（均P < 0.05）。皮质醇浓度也与相对腹部质量（P < 0.05）时，显着的糖尿病人被排除。结论：2型糖尿病的严重程度的几个临床措施与皮质醇浓度相关。此外，结果提供了证据，代谢紊乱和皮质醇浓度之间的正相关关系，在可接受的正常范围内。
Objective: The prevalence of type 2 diabetes mellitus is increasing rapidly in industrialized countries, and adrenal glucocorticoids may intensify this disease. We sought: to assess the relationship between diabetes-associated metabolic disturbances and cortisol concentrations in patients with type 2 diabetes.Design: We investigated 190 type 2 diabetic patients who volunteered from a population Study of 12 430 people in Luebeck and its suburbs. The target Population comprised men and women born between 1939 and 1958 who initially received it Postal questionnaire about their health status. We identified 346 subjects with confirmed diabetes mellitus and 216 patients participated in the study. Patients with type I diabetes were excluded.Methods: Five salivary cortisol samples were collected before and after lunch, in the evening and then the next morning before and after standing. Clinical variables associated with diabetes were measured and correlated with cortisol concentrations.Results: None of the cohort had salivary cortisol concentrations that exceeded the normally accepted range. Based on cortisol samples collected just prior to a standard lunch, the cohort was divided into tertiles. Cortisol wits positively related to: la,sting blood, urinary and postprandial glucose; glycosylated hemoglobin: and systolic and diastolic blood pressures (all P < 0.05). Cortisol concentrations also correlated with the relative abdominal mass (P < 0.05) when patients with marked glucosuria were excluded.Conclusions: The degree of severity of several clinical measures of type 2 diabetes correlates with cortisol concentrations. Moreover, the results provide evidence for a positive relationship between metabolic disturbances and cortisol concentrations that are within the accepted normal range.