The Influence of Metabolic Syndrome and Chronic Kidney Disease on Hemorheology Assessed by the Microchannel Method
The Influence of Metabolic Syndrome and Chronic Kidney Disease on Hemorheology Assessed by the Microchannel Method
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DOI：
10.2114/jpa2.29.157
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发表时间：
2010-09-01
影响因子：
3.1
通讯作者：
Shimatsu, Akira
中科院分区：
文献类型：
--
作者：
Kotani, Kazuhiko;Satoh, Noriko;Shimatsu, Akira
代谢综合征(METS)和慢性肾脏疾病(CKD)是心血管疾病(CVD)的个体危险因素。血液流变学的异常可能与这两种疾病的CVD有关。本研究探讨了蛋氨酸和慢性肾脏病对血液流变学的影响。我们研究了138名成年人(女性/男性=63/75，平均年龄=52.2岁)，其中包括87名患有METS的参与者和33名患有CKD的参与者。用微通道阵列流动分析仪(MC-FAN)测定全血通过时间(WBPT)评价血液流变学。METS参与者的WBPT值显著高于非METS参与者(52.5+/-13.1对46.3+/-7.7秒，p=0.03)。慢性肾脏病组的WBPT值显著高于非慢性肾脏病组(55.5±12.7vs.48.6+/-11.0s，p=0.003)。蛋氨酸和慢性肾脏病对WBPT有显著影响(P=0.04)。蛋氨酸和慢性肾脏病对WBPT的影响(59.9+/-13.4秒)明显大于非蛋氨酸和慢性肾脏病(46.6+/-3.5)或非慢性肾脏病和蛋氨酸(50.0+/-12.2)。与女性相比，METS和CKD的结合对男性的影响更明显。用MC-FAN评估的异常血液流变学可以通过蛋氨酸和CKD的联合应用而得到加强。J Physiol Anthropol29(5)：157160,2010年http://www.jstage.jst.go.jp/browse/jpa2[doi：10.2114/jpa2.29.157]
Metabolic syndrome (MetS) and chronic kidney disease (CKD) are individual risk factors for cardiovascular disease (CVD). Abnormal hemorheology may be associated with CVD in both disorders. The present study investigated the impact of MetS and CKD on hemorheology. We studied 138 adults (women/men=63/75, mean age=52.2 years), who included 87 participants with MetS and 33 with CKD. The hemorheology was assessed by the index of 'whole blood passage time (WBPT)' using the Micro Channel array Flow ANalyzer (MC-FAN). The WBPT values of MetS participants were significantly higher than those of non-MetS participants (52.5 +/- 13.1 vs. 46.3 +/- 7.7 sec, p=0.03). The WBPT values of CKD participants were significantly higher than those of non-CKD (55.5 +/- 12.7 vs. 48.6 +/- 11.0 sec, p=0.003). The significant influence of MetS and CKD on WBPT was qualified by their effect modification to WBPT (p=0.04). There was a significantly greater influence of the combination of MetS and CKD on WBPT (59.9 +/- 13.4 sec) in comparison to the influence of non-MetS and CKD (46.6 +/- 3.5) or non-CKD and MetS (50.0 +/- 12.2). The influence of the combination of MetS and CKD was clearer in men, relative to women. Abnormal hemorheology as assessed using MC-FAN may be enhanced by the combination of MetS and CKD. J Physiol Anthropol 29(5): 157-160, 2010 http://www.jstage.jst.go.jp/browse/jpa2 [DOI: 10.2114/jpa2.29.157]