Arc/Arg3.1 is essential for the consolidation of synaptic plasticity and memories
Arc/Arg3.1 is essential for the consolidation of synaptic plasticity and memories
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DOI：
10.1016/j.neuron.2006.08.024
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发表时间：
2006-11-09
期刊：
影响因子：
16.2
通讯作者：
Kuhl, Dietmar
中科院分区：
文献类型：
--
作者：
Plath, Niels;Ohana, Ora;Kuhl, Dietmar
ARC/Arg3.1由可塑性刺激强烈诱导，并专门针对刺激的突触区域。为了研究Arc/Arg3.1在突触可塑性和学习记忆中的作用，我们建立了Arc/Arg3.1基因敲除小鼠。这些动物无法形成对内隐和外显学习任务的长期记忆，尽管短期记忆完好无损。此外，它们还显示出海马齿状回和CA1区长时程增强的双相改变，早期和晚期增强。此外，长期抑郁会明显受损。综上所述，这些结果表明Arc/Arg3.1在巩固持久突触可塑性和记忆存储方面发挥了关键作用。
Arc/Arg3.1 is robustly induced by plasticity-producing stimulation and specifically targeted to stimulated synaptic areas. To investigate the role of Arc/Arg3.1 in synaptic plasticity and learning and memory, we generated Arc/Arg3.1 knockout mice. These animals fail to form long-lasting memories for implicit and explicit learning tasks, despite intact short-term memory. Moreover, they exhibit a biphasic alteration of hippocampal long-term potentiation in the dentate gyrus and area CA1 with an enhanced early and absent late phase. In addition, long-term depression is significantly impaired. Together, these results demonstrate a critical role for Arc/Arg3.1 in the consolidation of enduring synaptic plasticity and memory storage.