Prevalence of sexually transmitted infections in HIV-1 infected pregnant women in Europe
Prevalence of sexually transmitted infections in HIV-1 infected pregnant women in Europe
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DOI：
10.1007/s10654-007-9188-0
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发表时间：
2007-12-01
影响因子：
13.6
通讯作者：
Newell, Marie-Louise
中科院分区：
文献类型：
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作者：
Landes, Megan;Thorne, Claire;Newell, Marie-Louise
作为欧洲合作研究 (ECS) 中的一项嵌套研究，我们调查了一组感染 HIV-1 的孕妇中性传播感染 (STI) 的患病率，并描述了与 STI 诊断相关的因素。 ECS 是一项队列研究，根据标准临床和实验室方案，招募感染艾滋病毒的孕妇，并对其孩子进行出生后跟踪。怀孕期间诊断出的性传播感染的信息是从 1999 年 1 月至 2005 年 10 月期间登记的妇女的产前记录中回顾性收集的；其他变量是从 ECS 前瞻性数据库中获得的。共有 1,050 名女性参与其中：530 名来自西欧，520 名来自乌克兰。梅毒是最常见的细菌性 STI（患病率 2%，95% CI 1.2-3.0）。 HPV 相关生殖器病变的患病率为 8.6% (95%CI 6.9-10.4)，阴道毛滴虫的患病率为 12.1% (95%CI 10.2-14.2)。乌克兰女性（AOR 10.7，95%CI 3.7-30.5）、单身女性（AOR 3.9，95%CI 1.2-12.7）、注射吸毒者的性伴侣（AOR 3.8，95%CI 1.4-10.4）和 CD4 计数 < 200 个细胞/mm(3) 的女性（AOR 5.4，95%CI 1.0-28.1) 诊断沙眼衣原体、梅毒或阴道毛滴虫的风险增加。非洲血统（AOR 1.9，95%CI 1.1-3.3）和 CD4 计数 < 200 个细胞/mm(3)（AOR 3.4，95%CI 1.5-7.8）与 HSV-2 和/或 HPV 相关生殖器病变相关。产前筛查应被视为诊断、治疗和预防性传播感染进一步传播的有效工具。感染艾滋病毒的妇女应在怀孕期间接受充分的性传播感染筛查，并接受适当的咨询和后续治疗和预防。
We investigated prevalence of sexually transmitted infections (STI) in a cohort of HIV-1-infected pregnant women and described factors associated with STI diagnosis, as a nested study within the European Collaborative Study (ECS). The ECS is a cohort study in which HIV-infected pregnant women are enrolled and their children followed from birth, according to standard clinical and laboratory protocols. Information on STIs diagnosed during pregnancy was collected retrospectively from the antenatal records of women enrolling between January 1999 and October 2005; other variables were obtained from the ECS prospective database. A total of 1,050 women were included: 530 in Western Europe and 520 in Ukraine. Syphilis was the most common bacterial STI (2% prevalence, 95% CI 1.2-3.0). Prevalence of HPV-related genital lesions was 8.6% (95%CI 6.9-10.4) and prevalence of Trichomonas vaginalis was 12.1% (95%CI 10.2-14.2). Women in Ukraine (AOR 10.7, 95%CI 3.7-30.5), single women (AOR 3.9, 95%CI 1.2-12.7), sexual partners of injecting drug users (AOR 3.8, 95%CI 1.4-10.4) and women with CD4 counts < 200 cells/mm(3) (AOR 5.4, 95%CI 1.0-28.1) were at increased risk of diagnosis with Chlamydia trachomatis, syphilis or Trichomonas vaginalis. African origin (AOR 1.9, 95%CI 1.1-3.3) and CD4 count < 200 cells/mm(3) (AOR 3.4, 95%CI 1.5-7.8) were associated with HSV-2 and/or HPV-related genital lesions. Antenatal screening should be considered an effective tool for diagnosis, treatment and prevention of further transmission of STIs. HIV-infected women should receive adequate screening for STIs during pregnancy together with appropriate counseling and follow-up for treatment and prevention.