miRNA-192 and-215 activate Wnt/β-catenin signaling pathway in gastric cancer via APC
miRNA-192 and-215 activate Wnt/β-catenin signaling pathway in gastric cancer via APC
复制标题
miRNA-192和-215通过APC激活胃癌中的Wnt/β-catenin信号通路
DOI：
10.1002/jcp.29550
复制
发表时间：
2020-09-01
影响因子：
5.6
通讯作者：
Jin, Zhe
中科院分区：
文献类型：
--
作者：
Deng, Shiqi;Zhang, Xiaojing;Jin, Zhe
Although great progress has been made in surgical techniques, traditional radiotherapy, and chemotherapy, gastric cancer (GC) is still the most common malignant tumor and has a high mortality, which highlights the importance of novel diagnostic markers. Emerging studies suggest that different microRNAs (miRNAs) are involved in tumorigenesis of GC. In this study, we found that miRNA-192 and -215 are significantly upregulated in GC and promote cell proliferation and migration. Adenomatous polyposis coli (APC), a well-known negative regulator in Wnt signaling, has been proved to be a target of miRNA-192 and -215. Inhibition of miRNA-192 or -215 reduced the Topflash activities and repressed the expression of Wnt signaling pathway proteins, while APC small interfering RNAs reversed the inhibitory effects, suggesting that miRNA-192 and -215 activate Wnt signaling via APC. In addition, APC mediates the cell proliferation and migration regulated by miRNA-192 and -215. Furthermore, APC is downregulated in GC tissues and negatively correlated with the expression of miRNA-192 and -215. In summary, miRNA-192 and -215 target APC and function as oncogenic miRNAs by activating Wnt signaling in GC, revealing to be potential therapeutic targets.
