Epidemiological features and clinical manifestations in 469 adult patients with brucellosis in Babol, Northern Iran
Epidemiological features and clinical manifestations in 469 adult patients with brucellosis in Babol, Northern Iran
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DOI：
10.1017/s0950268804002833
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发表时间：
2004-12-01
影响因子：
4.2
通讯作者：
Hajiahmadi, M
中科院分区：
文献类型：
--
作者：
Roushan, MRH;Mohrez, M;Hajiahmadi, M
对1997~2002年伊朗巴布尔医科大学感染科收治的成人布鲁氏菌病病例的流行病学特征和临床表现进行了调查。在469例中，267例(56.9%)为男性。病例平均年龄为36(.)9+/-15岁。大多数(60%.8%)来自农村地区。三分之二的病例(306例，66(.)3%)发生在春季或夏季。主要危险因素为新鲜奶酪(22.4%)、畜牧业(11.3%)、实验室工作人员(8.1%)和兽医职业(1.5%)。45个家庭(9(.)6%)有两个病例。出汗、发热、关节痛是最常见的临床症状。有记录的并发症有男性105例(39%)和女性41例(20%)，P=0(0001)。周围性关节炎见于24名男性(9%)和19名女性(9.4%)，其中膝盖和臀部是最常见的感染部位。其中，28例(6%)为腰椎炎，32例(6%)为脊柱炎，男性多见(P=0.023)。29例(10.9%)男性出现附睾炎。心内膜炎3例(0%)，神经系统并发症0例(6%)。大多数布鲁氏菌病患者没有任何已知的布鲁氏菌病危险因素。因此，食用不安全的乳制品可能是感染的主要途径。本病临床表现多样，并发症多。男性的并发症比女性更常见。
The epidemiological features and clinical manifestations of adult cases of brucellosis admitted to the Department of Infectious Diseases, Babol Medical University, Iran from 1997 to 2002 were investigated. Of 469 cases, 267 (56(.)9%) were males. The mean age of cases was 36(.)9 +/- 15 years. Most (60(.)8%) were from rural areas. Two thirds of cases (306, 66(.)3%) presented during spring or summer. Fresh cheese (22(.)4%), animal husbandry (11(.)3%), laboratory worker (8(.)1%) and veterinary profession (1(.)5%) were the main risk factors. Forty-five families (9(.)6%) had two cases. Sweating, fever, and arthralgia were the most frequent clinical symptoms. Complications were documented in 105 males (39(.)5%) and 41 females (20(.)3%, P=0(.)0001). Peripheral arthritis was seen in 24 (9%) males and 19 (9(.)4%) females, with knees and hips being the most common sites of infection. Sacroiliitis and spondylitis were seen in 28 (6%) and 32 (6(.)8%) cases respectively with spondylitis more common in males (P=0(.)023). Epididymo-orchitis was seen in 29 (10(.)9%) males. There were three cases each of endocarditis (0(.)6%) and neurological complications (0(.)6%). Most patients with brucellosis did not have any of the known risk factors for brucellosis. Thus consumption Of unsafe dairy products could be the main route of infection. The disease manifested with a diversity of clinical manifestations and complications. Complications were more frequent in males than females.