GROWTH-HORMONE SECRETORY PROFILES - VARIATION ON CONSECUTIVE NIGHTS
GROWTH-HORMONE SECRETORY PROFILES - VARIATION ON CONSECUTIVE NIGHTS
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DOI：
10.1016/s0022-3476(89)80328-2
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发表时间：
1989-07-01
影响因子：
5.1
通讯作者：
MOORE, WV
中科院分区：
文献类型：
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作者：
DONALDSON, DL;HOLLOWELL, JG;MOORE, WV
为了评价夜间生长激素(GH)检测的重复性和白天应用左旋多巴和可乐定对夜间GH分泌的影响，我们对48名5~16岁的矮个子受试者进行了连续12小时的夜间GH检测。在6名受试者(12%)中，第二晚的过夜GH浓度比第一晚的结果(夜间变化+1.2~+5.2 ng/ml)增加了100%。在其余受试者中，生长激素池中生长激素浓度的夜间变化范围为-1.2至+1.8 ng/ml(与第一个夜间值相比变化-60%至+88%)。夜间变化为首夜值的25%的受试者17人(35%)，25%至50%的受试者18人(38%)，50%至100%的受试者7人(15%)。池中生长激素浓度的夜间变化与夜间生长激素峰值浓度的差异有关，但与观察到的睡眠时间的差异无关。白天给予左旋多巴-可乐定对过夜池生长激素浓度没有明显影响。这些结果证明了夜间生长激素水平的夜间变化的可能性，并提示需要一些手段来证实夜间生长激素检测反映了正常的生理性生长激素分泌。如果没有这样的确认，单次夜间生长激素曲线的结果应谨慎解释。
To evaluate the reproducibility of overnight growth hormone (GH) testing and the effect of daytime adminstration of levodopa and clonidine on overnight GH secretion, we examined consecutive 12-hour overnight HG profiles of 48 short subjects, ages 5 to 16 years, who had GH stimulation testing with levodopa and clonidine. In six subjects (12%) the overnight pool GH concentration on the second night increased by > 100% from the first-night result (night-to-night) changes of +1.2 to +5.2 ng/ml). In the remaining subjects, night-to-night changes in pool GH concentrations ranged from -1.2 to +1.8 ng/ml (-60% to +88% changes from the first night value). Night-to-night changes were < 25% of the first-night value in 17 subjects (35%), 25% to 50% in 18 subjects (38%), and 50% to 100% in 7 subjects (15%). Night-to-night changes in pool GH concentrations correlated with differences in peak nighttime GH concentrations but not with differences in duration of observed sleep. There was no discernible effect of daytime levodopa-clonidine administration on overnight pool GH concentrations. These results demonstrate the potential for night-to-night variation in overnight GH profiles and suggest the need for some means of confirming that overnight GH testing reflects normal physiologic GH secretion. Without such confirmation, the results from a single overnight GH profile should be interpreted with caution.