Pathogenicity of a highly pathogenic avian influenza virus, A/chicken/Yamaguchi/7/04 (H5N1) in different species of birds and mammals
Pathogenicity of a highly pathogenic avian influenza virus, A/chicken/Yamaguchi/7/04 (H5N1) in different species of birds and mammals
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DOI：
10.1007/s00705-005-0723-6
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发表时间：
2006-07-01
影响因子：
2.7
通讯作者：
Kida, H.
中科院分区：
文献类型：
--
作者：
Isoda, N.;Sakoda, Y.;Kida, H.
自1996年以来，亚洲家禽中一直爆发高致病性禽流感（HPAI）。2004年初，日本不同地区的两个农场和一群宠物鸡爆发了由H5N1病毒引起的HPAI疫情。在本研究中，A/chicken/Yamaguchi/7/04 (H5N1) 是在日本首次爆发期间从死鸡中分离出来的，通过实验感染对鸡、鹌鹑、虎皮鹦鹉、小鸭、小鼠和小型猪进行了致病性评估。该病毒对所有测试的鸟类均具有高致病性。小鼠易感染且死亡率低，小型猪对该病毒具有抵抗力。
Outbreaks of highly pathogenic avian influenza (HPAI) have been occurring in domestic poultry in Asia since 1996. In the beginning of 2004, HPAI outbreaks were caused by H5N1 virus in two farms and a group of pet chickens in different areas of Japan. In the present study, the pathogenicity of A/chicken/Yamaguchi/7/04 (H5N1), which had been isolated from a dead chicken during the first outbreak in Japan, was assessed in chickens, quails, budgerigars, ducklings, mice, and miniature pigs by experimental infection. The virus was highly pathogenic to all the birds tested. Mice were susceptible to infection with a low mortality rate and miniature pigs were resistant to infection with the virus.