Potential Role of Ginseng in the Treatment of Colorectal Cancer
Potential Role of Ginseng in the Treatment of Colorectal Cancer
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DOI：
10.1142/s0192415x08006545
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发表时间：
2008-01-01
影响因子：
5.7
通讯作者：
Yuan, Chun-Su
中科院分区：
文献类型：
--
作者：
Wang, Chong-Zhi;Yuan, Chun-Su
结直肠癌仍然是美国最常见的癌症之一，也是癌症相关死亡的主要原因。许多目前使用的化学治疗剂来源于植物。确定草药来源，包括人参家族，以开发更好的抗癌疗法仍然是推进癌症治疗的重要一步。在这篇文章中，人参草药，特别是西洋参和三七，在大肠癌治疗的潜在作用。人参的主要药理活性成分是人参皂苷，主要分为原人参二醇组和原人参三醇组。讨论了它们的化学结构与药理活性之间的构效关系。另外，不同的蒸制温度和时间处理人参药材，可以改变人参药材的生物学特性，增强其抗癌活性。这种热处理过程可能会增加人参在治疗结直肠癌中的作用。
Colorectal cancer remains one of the most prevalent cancer and a leading cause of cancer related death in the US. Many currently used chemotherapeutic agents are derived from botanicals. Identifying herbal sources, including those from ginseng family, to develop better anti-cancer therapies remains an essential step in advancing the treatment of the cancer. In this article, potential roles of ginseng herbs, especially American ginseng and notoginseng, in colorectal cancer therapeutics are presented. The major pharmacologically active constituents of ginsengs are ginsenosides, which can be mainly classified as protopanaxadiol and protopanaxatriol groups. Structure-activity relationship between their chemical structures and pharmacological activities are discussed. In addition, various steaming temperature and time treatment of the ginseng herbs can change ginsenoside profiles, and enhance their anti-cancer activities. This heat treatment process may increase the role of ginseng in treating colorectal cancer.