Cardioprotective Role of Caveolae in Ischemia-Reperfusion Injury.
Cardioprotective Role of Caveolae in Ischemia-Reperfusion Injury.
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DOI：
10.4172/2161-1025.1000114
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发表时间：
2013-09
期刊：
影响因子：
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通讯作者：
Junhui Sun;T. Nguyen;Mark J. Kohr;E. Murphy
中科院分区：
文献类型：
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作者：
Junhui Sun;T. Nguyen;Mark J. Kohr;E. Murphy
小窝是富含胆固醇、鞘脂、标记蛋白小窝蛋白和外壳蛋白小窝蛋白的质膜的烧瓶状内陷。在心肌细胞中，多种信号分子集中并组织在小窝内以介导信号转导。近年来的研究表明，小窝及其相关信号分子在心肌缺血再灌注损伤中起重要的保护作用。例如，caveolin-3的心脏特异性过表达已显示导致模拟缺血预处理的保护，而caveolin-3的敲除废除缺血预处理。在这篇综述中，我们讨论了参与小窝介导的心脏保护的分子机制和信号通路，并研究了小窝作为药物干预治疗心血管疾病的治疗靶点的潜力。
Caveolae are flask-like invaginations of the plasma membrane enriched in cholesterol, sphingolipids, the marker protein caveolin and the coat protein cavin. In cardiomyocytes, multiple signaling molecules are concentrated and organized within the caveolae to mediate signaling transduction. Recent studies suggest that caveolae and caveolae-associated signaling molecules play an important role in protecting the myocardium against ischemia-reperfusion injury. For example, cardiac-specific overexpression of caveolin-3 has been shown to lead to protection that mimics ischemic preconditioning, while the knockout of caveolin-3 abolished ischemic preconditioning. In this review, we discuss the molecular mechanisms and signaling pathways that are involved in caveolae-mediated cardioprotection, and examine the potential for caveolae as a therapeutic target for pharmaceutical intervention to treat cardiovascular disease.