β-Adrenoceptor Signaling Networks in Adipocytes for Recruiting Stored Fat and Energy Expenditure.
β-Adrenoceptor Signaling Networks in Adipocytes for Recruiting Stored Fat and Energy Expenditure.
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DOI：
10.3389/fendo.2011.00102
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发表时间：
2011
影响因子：
5.2
通讯作者：
Collins S
中科院分区：
文献类型：
--
作者：
Collins S
脂肪细胞就像一个银行：一个在充足时期储存多余（热量）现金的地方，在“不景气时期”可以从中提取储蓄。β-肾上腺素受体（βAR）是动员脂肪在其他组织中消耗的通道。本文就白色和棕色脂肪细胞中βAR信号通路的研究进展作一综述。在啮齿动物模型中的研究表明，棕色脂肪细胞与白色脂肪库相关联，并且被认为是抵抗饮食诱导的肥胖的关键使能因素。由于现在认识到成年人有棕色脂肪细胞，了解这些信号通路中的步骤可能会提供操纵脂肪细胞成为能量净消费者的机会。
The adipocyte is like a bank: a place to store excess (caloric) cash in times of plenty, and from which one can withdraw savings during “lean times.” The β-adrenoceptors (βAR) are the gateways to this mobilization of fat to be consumed in other tissues. This review discusses the βAR signaling pathway(s) in white and brown adipocytes. Studies in rodent models show that brown adipocytes nestled with white fat depots correlate with and are considered a key enabling factor in resistance to diet-induced obesity. Since it is now recognized that adult humans have brown adipocytes, knowing the steps in these signaling pathways may provide the opportunity to manipulate adipocytes to be net consumers of energy.