Tractography of the corticospinal tracts in infants with focal perinatal injury: comparison with normal controls and to motor development
Tractography of the corticospinal tracts in infants with focal perinatal injury: comparison with normal controls and to motor development
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DOI：
10.1007/s00234-011-0969-5
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发表时间：
2012-05-01
期刊：
影响因子：
2.8
通讯作者：
Counsell, Serena J.
中科院分区：
文献类型：
--
作者：
Roze, Elise;Harris, Polly A.;Counsell, Serena J.
我们的目的是（1）评估皮质脊髓束（CST）的婴儿局灶性损伤和健康足月对照（2）相关的常规磁共振成像（MRI）和纤维束成像的结果与他们以后的运动功能。我们研究了20个婴儿局灶性病变和23个对照组使用MRI和扩散张量成像。测定各节段的道体积、各向异性分数（FA）、表观扩散系数（ADC）值、轴向扩散系数和径向扩散系数（RD）。通过比较同侧与对侧CST计算不对称指数（AI）。常规MRI能够预测正常运动发育（n = 9）或偏瘫（n = 6）。在轻度运动不对称的儿童中（n = 5），常规MRI预测2例偏瘫，3例运动发育正常。对照组和患偏瘫的婴儿之间的气道容积、FA、ADC和RD的AI存在显著性差异，而对照组和患轻度不对称的婴儿之间的AI也存在显著性差异，常规MRI能够预测随后新生儿局灶性损伤后的正常运动发育或偏瘫。从弥散纤维束成像获得的RD的措施可以提供额外的信息，用于预测随后的运动功能不对称。
Our aims were to (1) assess the corticospinal tracts (CSTs) in infants with focal injury and healthy term controls using probabilistic tractography and (2) to correlate the conventional magnetic resonance imaging (MRI) and tractography findings in infants with focal injury with their later motor function.We studied 20 infants with focal lesions and 23 controls using MRI and diffusion tensor imaging. Tract volume, fractional anisotropy (FA), apparent diffusion coefficient (ADC) values, axial diffusivity and radial diffusivity (RD) of the CSTs were determined. Asymmetry indices (AIs) were calculated by comparing ipsilateral to contralateral CSTs. Motor outcome was assessed using a standardized neurological examination.Conventional MRI was able to predict normal motor development (n = 9) or hemiplegia (n = 6). In children who developed a mild motor asymmetry (n = 5), conventional MRI predicted a hemiplegia in two and normal motor development in three infants. The AIs for tract volume, FA, ADC and RD showed a significant difference between controls and infants who developed a hemiplegia, and RD also showed a significant difference in AI between controls and infants who developed a mild asymmetry.Conventional MRI was able to predict subsequent normal motor development or hemiplegia following focal injury in newborn infants. Measures of RD obtained from diffusion tractography may offer additional information for predicting a subsequent asymmetry in motor function.