Changes in cardiac output and total peripheral resistance during the carotid sinus baroreceptor reflex in the pregnant rabbit.
Changes in cardiac output and total peripheral resistance during the carotid sinus baroreceptor reflex in the pregnant rabbit.
复制标题
妊娠兔颈动脉窦压力感受器反射期间心输出量和总外周阻力的变化。
DOI：
10.1113/jphysiol.1977.sp012033
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发表时间：
1977
期刊：
影响因子：
--
通讯作者：
N. Joels
中科院分区：
文献类型：
--
作者：
P. Humphreys;N. Joels
1. 在十六只麻醉的怀孕兔子中检查了离体颈动脉窦内压力变化对心血管的反射影响。 2. 窦压为 40 和 200 mmHg 时的平均结果比较显示，心率下降了 32.1 次 min-1，动脉压下降了 48.2 mmHg。通过热稀释测量的心输出量下降了 25.7 毫升。 min-1.kg-1 和总外周阻力降低 0-292 mmHg。毫升‐1 分钟公斤。 3. 之前报道的 17 只非怀孕雌性兔子的相应变化是心率下降了 34.5 次/分钟，但动脉压显着下降了 69-8 mmHg，总外周阻力下降了 0-432 mmHg。 ml.‐1 分钟.kg.然而，心输出量 12.6 ml.min-1.kg-1 的下降幅度明显较小。 4. 这些观察结果表明，怀孕兔对窦压变化的血压反应较小，这是由于总外周阻力变化减少。
1. The reflex cardiovascular effects of changes in pressure within the isolated carotid sinus have been examined in sixteen anaesthetized pregnant rabbits. 2. Comparison of the mean results at sinus pressures of 40 and 200 mmHg showed that heart rate fell by 32.1 beats min‐1 and arterial pressure was reduced by 48.2 mmHg. Cardiac output, measured by thermal dilution, fell by 25.7 ml. min‐1.kg‐1 and total peripheral resistance was reduced by 0‐292 mmHg. ml.‐1 min. kg. 3. The corresponding changes previously reported in a group of seventeen non‐pregnant female rabbits were a similar fall in heart rate of 34.5 beats min‐1 but significantly greater reductions in arterial pressure of 69‐8 mmHg and in total peripheral resistance of 0‐432 mmHg. ml.‐1 min.kg. However, the fall in cardiac output of 12.6 ml.min‐1.kg‐1 was significantly smaller. 4. These observations show that the smaller blood pressure response of the pregnant rabbit to alterations in sinus pressure is due to a reduced change in total peripheral resistance.